MUTATION FREQUENCY IN NURSES AND PHARMACISTS WORKING WITH CYTOTOXIC DRUGS

A. CHRYSOSTOMOU, R. SESHADRI, A. A. MORLEY

    Research output: Contribution to journalArticle

    47 Citations (Scopus)

    Abstract

    Individuals occupationally exposed to cytotoxic drugs may be at risk owing to the effects of these agents on DNA. As an index of DNA damage, in vivo mutations were measured in lymphocytes from 24 oncology nurses or pharmacists and 24 matched controls. Mutation frequency was significantly increased in exposed individuals and appeared to be related to duration of exposure. However, the overall magnitude of the increase was small and its biological significance remains to be determined.

    Original languageEnglish
    Pages (from-to)831-834
    Number of pages4
    JournalAustralian and New Zealand Journal of Medicine
    Volume14
    Issue number6
    DOIs
    Publication statusPublished - Dec 1984

    Keywords

    • cytotoxic drugs
    • lymphocytes
    • Mutations
    • nurses
    • occupational health
    • pharmacists

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