Nanofibrillar thermoreversible micellar microgels

Diego Velasco; Mokit Chau; Héloïse Thérien-Aubin; Alexander Kumachev; Ethan Tumarkin; Zhongfan Jia; Gilbert C. Walker; Michael J. Monteiro; Eugenia Kumacheva

doi:10.1039/c2sm27796d

Nanofibrillar thermoreversible micellar microgels

Diego Velasco, Mokit Chau, Héloïse Thérien-Aubin, Alexander Kumachev, Ethan Tumarkin, Zhongfan Jia, Gilbert C. Walker, Michael J. Monteiro, Eugenia Kumacheva

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

By using microfluidics, we generated micellar nanofibrillar microgels from solutions of worm-like micelles of poly(N-isopropyl acrylamide)-block- polystyrene. The microgels were formed under physiological conditions (pH = 7.4, 37 °C) and rapidly dissociated upon cooling to 25-27 °C, thereby enabling cell encapsulation and release for further characterization. Our work offers a new concept for the generation of dynamic artificial three-dimensional microenvironments for studies of cell fate.

Original language	English
Pages (from-to)	2380-2383
Number of pages	4
Journal	Soft Matter
Volume	9
Issue number	8
DOIs	https://doi.org/10.1039/c2sm27796d
Publication status	Published - 28 Feb 2013
Externally published	Yes

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AU - Velasco, Diego

AU - Chau, Mokit

AU - Thérien-Aubin, Héloïse

AU - Kumachev, Alexander

AU - Tumarkin, Ethan

AU - Jia, Zhongfan

AU - Walker, Gilbert C.

AU - Monteiro, Michael J.

AU - Kumacheva, Eugenia

PY - 2013/2/28

Y1 - 2013/2/28

N2 - By using microfluidics, we generated micellar nanofibrillar microgels from solutions of worm-like micelles of poly(N-isopropyl acrylamide)-block- polystyrene. The microgels were formed under physiological conditions (pH = 7.4, 37 °C) and rapidly dissociated upon cooling to 25-27 °C, thereby enabling cell encapsulation and release for further characterization. Our work offers a new concept for the generation of dynamic artificial three-dimensional microenvironments for studies of cell fate.

AB - By using microfluidics, we generated micellar nanofibrillar microgels from solutions of worm-like micelles of poly(N-isopropyl acrylamide)-block- polystyrene. The microgels were formed under physiological conditions (pH = 7.4, 37 °C) and rapidly dissociated upon cooling to 25-27 °C, thereby enabling cell encapsulation and release for further characterization. Our work offers a new concept for the generation of dynamic artificial three-dimensional microenvironments for studies of cell fate.

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JO - Soft Matter

JF - Soft Matter

SN - 1744-683X

IS - 8

ER -

Nanofibrillar thermoreversible micellar microgels

Abstract

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