Nanoparticles in an antibiotic-loaded nanomesh for drug delivery

Melanie A Fuller; Ashley  Carey; Harriet Whiley; Rio Kurimoto; Mitsuhiro Ebara; Ingo Köper

doi:10.1039/c9ra06398f

Nanoparticles in an antibiotic-loaded nanomesh for drug delivery

Melanie A Fuller, Ashley Carey, Harriet Whiley, Rio Kurimoto, Mitsuhiro Ebara, Ingo Köper

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

26 Downloads (Pure)

Abstract

Antibiotic loaded nanomeshes were fabricated by electrospinning polycaprolactone, a biocompatible polymer, with 12.5% w/w Colistin, 1.4% w/w Vancomycin and either cationic or anionic gold nanoparticles in varying combinations. The resulting nanomeshes had different antibiotic release profiles, with citrate capped gold nanoparticles combined with Colistin having the highest sustained release over 14 days for a 4 mg, 1.5 cm² nanomesh. The electrospinning parameters were optimised to ensure the spinning of a homogenous mesh and the addition of antibiotics was confirmed through ¹H NMR and ATR-FTIR. This research, as a proof of concept, suggests an opportunity for fabricating nanomeshes which contain gold nanoparticles as a drug release mechanism for antibiotics.

Original language	English
Pages (from-to)	30064-30070
Number of pages	7
Journal	RSC Advances
Volume	9
Issue number	52
DOIs	https://doi.org/10.1039/c9ra06398f
Publication status	Published - 24 Sept 2019

Bibliographical note

This is an open access article under the terms of the Creative Commons BY-NC Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Keywords

nanoparticles
nanomesh
antibiotic

Access to Document

10.1039/c9ra06398fLicence: CC BY-NC

Fuller_Nanoparticles_P2019Final published version, 681 KBLicence: CC BY-NC

Cite this

@article{217a89cab243472b9e75b800b89931ba,

title = "Nanoparticles in an antibiotic-loaded nanomesh for drug delivery",

abstract = "Antibiotic loaded nanomeshes were fabricated by electrospinning polycaprolactone, a biocompatible polymer, with 12.5% w/w Colistin, 1.4% w/w Vancomycin and either cationic or anionic gold nanoparticles in varying combinations. The resulting nanomeshes had different antibiotic release profiles, with citrate capped gold nanoparticles combined with Colistin having the highest sustained release over 14 days for a 4 mg, 1.5 cm2 nanomesh. The electrospinning parameters were optimised to ensure the spinning of a homogenous mesh and the addition of antibiotics was confirmed through 1H NMR and ATR-FTIR. This research, as a proof of concept, suggests an opportunity for fabricating nanomeshes which contain gold nanoparticles as a drug release mechanism for antibiotics.",

keywords = "nanoparticles, nanomesh, antibiotic",

author = "Fuller, {Melanie A} and Ashley Carey and Harriet Whiley and Rio Kurimoto and Mitsuhiro Ebara and Ingo K{\"o}per",

note = "This is an open access article under the terms of the Creative Commons BY-NC Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.",

year = "2019",

month = sep,

day = "24",

doi = "10.1039/c9ra06398f",

language = "English",

volume = "9",

pages = "30064--30070",

journal = "RSC Advances",

issn = "2046-2069",

publisher = "Royal Society of Chemistry",

number = "52",

}

TY - JOUR

T1 - Nanoparticles in an antibiotic-loaded nanomesh for drug delivery

AU - Fuller, Melanie A

AU - Carey, Ashley

AU - Whiley, Harriet

AU - Kurimoto, Rio

AU - Ebara, Mitsuhiro

AU - Köper, Ingo

N1 - This is an open access article under the terms of the Creative Commons BY-NC Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PY - 2019/9/24

Y1 - 2019/9/24

N2 - Antibiotic loaded nanomeshes were fabricated by electrospinning polycaprolactone, a biocompatible polymer, with 12.5% w/w Colistin, 1.4% w/w Vancomycin and either cationic or anionic gold nanoparticles in varying combinations. The resulting nanomeshes had different antibiotic release profiles, with citrate capped gold nanoparticles combined with Colistin having the highest sustained release over 14 days for a 4 mg, 1.5 cm2 nanomesh. The electrospinning parameters were optimised to ensure the spinning of a homogenous mesh and the addition of antibiotics was confirmed through 1H NMR and ATR-FTIR. This research, as a proof of concept, suggests an opportunity for fabricating nanomeshes which contain gold nanoparticles as a drug release mechanism for antibiotics.

AB - Antibiotic loaded nanomeshes were fabricated by electrospinning polycaprolactone, a biocompatible polymer, with 12.5% w/w Colistin, 1.4% w/w Vancomycin and either cationic or anionic gold nanoparticles in varying combinations. The resulting nanomeshes had different antibiotic release profiles, with citrate capped gold nanoparticles combined with Colistin having the highest sustained release over 14 days for a 4 mg, 1.5 cm2 nanomesh. The electrospinning parameters were optimised to ensure the spinning of a homogenous mesh and the addition of antibiotics was confirmed through 1H NMR and ATR-FTIR. This research, as a proof of concept, suggests an opportunity for fabricating nanomeshes which contain gold nanoparticles as a drug release mechanism for antibiotics.

KW - nanoparticles

KW - nanomesh

KW - antibiotic

UR - http://www.scopus.com/inward/record.url?scp=85072748915&partnerID=8YFLogxK

U2 - 10.1039/c9ra06398f

DO - 10.1039/c9ra06398f

M3 - Article

AN - SCOPUS:85072748915

SN - 2046-2069

VL - 9

SP - 30064

EP - 30070

JO - RSC Advances

JF - RSC Advances

IS - 52

ER -

Nanoparticles in an antibiotic-loaded nanomesh for drug delivery

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this