Natural history of chronic kidney disease in Australian Indigenous and non-Indigenous children: a 4-year population-based follow-up study

Leigh Haysom, Rita Williams, Elisabeth M. Hodson, Pamela A. Lopez-Vargas, Leslie P Roy, David M. Lyle, Jonathan C. Craig

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: To describe the natural history and risk of early chronic kidney disease (CKD) in Indigenous Australian populations.

Design, setting and participants: A prospective cohort of 2266 Aboriginal and non-Aboriginal children enrolled from primary schools throughout New South Wales from February 2002 to June 2004 and followed for 4 years.

Main outcome measures: Urinalysis, height, weight, blood pressure, birthweight and sociodemographic status at baseline and 2- and 4-year follow-up; CKD risk factors: haematuria, albuminuria, obesity, and systolic and diastolic hypertension.

Results: 2266 children (55% Aboriginal; 51% male; mean age, 8.9 years [SD, 2.0 years]) were enrolled at baseline. 1432 children (63%) were retested at 2-year follow-up, and 1506 children (67%) at 4-year follow-up. Prevalence of baseline CKD risk factors was frequent (2%–7%), but most abnormalities were transient. Besides persistent obesity (5.0%), persistence of CKD risk factors at final follow-up was low: haematuria (1.9%), albuminuria (2.4%), systolic hypertension (1.5%) and diastolic hypertension (0.2%). There was no difference in prevalence of persistent CKD risk factors between Aboriginal and non-Aboriginal children.

Conclusions: Over 4 years of follow-up, Indigenous Australian children had no increased risk for early evidence of CKD. More than 70% of baseline risk factors were transient, and persistent risk factors were uncommon. Our findings suggest the increased risk for end-stage kidney disease seen in Indigenous adults is not yet manifest in these schoolchildren, and may be potentially preventable.
Original languageEnglish
Pages (from-to)303-306
Number of pages4
JournalMedical Journal of Australia
Volume190
Issue number6
DOIs
Publication statusPublished - 16 Mar 2009

Keywords

  • kidney disease
  • indigenous health
  • epidemic
  • risk factors

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