Naturally occurring polyphenolic inhibitors of amyloid beta aggregation

Quentin Churches, Joanne Caine, Kate Cavanagh, Vidana Chandana Epa, Lynne Waddington, C Tranberg, Adam Meyer, J Varghese, Victor Streltsov, Peter Duggan

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    Abstract

    Alzheimer's disease is the most common neurodegenerative disease and is one of the main causes of death in developed countries. Consumption of foods rich in polyphenolics is strongly correlated with reduced incidence of Alzheimer's disease. Our study has investigated the biological activity of previously untested polyphenolic compounds in preventing amyloid β aggregation. The anti-aggregatory potential of these compounds was assessed using the Thioflavin-T assay, transmission electron microscopy, dynamic light scattering and size exclusion chromatography. Two structurally related compounds, luteolin and transilitin were identified as potent inhibitors of Aβ fibril formation. Computational docking studies with an X-ray derived oligomeric structure offer a rationale for the inhibitory activity observed and may facilitate development of improved inhibitors of Aβ aggregation and toxicity.

    Original languageEnglish
    Pages (from-to)3108-3112
    Number of pages5
    JournalBioorganic & Medicinal Chemistry Letters
    Volume24
    Issue number14
    DOIs
    Publication statusPublished - 2014

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  • Cite this

    Churches, Q., Caine, J., Cavanagh, K., Chandana Epa, V., Waddington, L., Tranberg, C., Meyer, A., Varghese, J., Streltsov, V., & Duggan, P. (2014). Naturally occurring polyphenolic inhibitors of amyloid beta aggregation. Bioorganic & Medicinal Chemistry Letters, 24(14), 3108-3112. https://doi.org/10.1016/j.bmcl.2014.05.008