Necrobiotic xanthogranuloma with cutaneous and cerebral manifestations: Case report and review of the literature

Kiritkumar Chhanalal Shah, Santosh Isaac Poonnoose, Renu George, Mary Jacob, Vedantam Rajshekhar

Research output: Contribution to journalReview articlepeer-review

24 Citations (Scopus)

Abstract

Necrobiotic xanthogranuloma (NXG) is a rare inflammatory histiocytic disease of the skin. Xanthogranuloma of the central nervous system is rare and few cases have been reported. To the authors' knowledge, there has been no previously reported case of NXG in which an intracranial lesion was found. This 52-year-old man, in whom NXG with all its cutaneous manifestations had been diagnosed, presented with three episodes of generalized tonic-clonic seizures. A contrast-enhanced computerized tomography scan of his brain revealed a bifrontal, dura-based mass lesion. The lesion was excised and reported to be an NXG that was similar, but not identical to the skin lesions. The patient was placed on a regimen of antiepileptic drug and chlorambucil after surgery.

Original languageEnglish
Pages (from-to)1111-1114
Number of pages4
JournalJOURNAL OF NEUROSURGERY
Volume100
Issue number6
DOIs
Publication statusPublished - Jun 2004
Externally publishedYes

Keywords

  • Brain neoplasm
  • Necrobiotic xanthogranuloma

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