Neolithic mitochondrial Haplogroup H genomes and the genetic origins of Europeans

Paul Brotherton; Wolfgang Haak; Jennifer Templeton; Guido Brandt; Julien Soubrier; Christina Adler; S Richards; Clio Der Sarkissian; Robert Ganslmeier; Susanne Friederich; Veit Dresely; Mannis van Oven; Rosalie Kenyon; Mark Van der Hoek; Jonas Korlach; Khai Luong; Simon Ho; Lluís Quintana-Murci; Doron Behar; Harald Meller; Kurt Alt; Alan Cooper

doi:10.1038/ncomms2656

Neolithic mitochondrial Haplogroup H genomes and the genetic origins of Europeans

Paul Brotherton, Wolfgang Haak, Jennifer Templeton, Guido Brandt, Julien Soubrier, Christina Adler, S Richards, Clio Der Sarkissian, Robert Ganslmeier, Susanne Friederich, Veit Dresely, Mannis van Oven, Rosalie Kenyon, Mark Van der Hoek, Jonas Korlach, Khai Luong, Simon Ho, Lluís Quintana-Murci, Doron Behar, Harald MellerKurt Alt, Alan Cooper

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179 Citations (Scopus)

Abstract

Haplogroup H dominates present-day Western European mitochondrial DNA variability (>40%), yet was less common (∼19%) among Early Neolithic farmers (∼5450 BC) and virtually absent in Mesolithic hunter-gatherers. Here we investigate this major component of the maternal population history of modern Europeans and sequence 39 complete haplogroup H mitochondrial genomes from ancient human remains. We then compare this 'real-time' genetic data with cultural changes taking place between the Early Neolithic (∼5450 BC) and Bronze Age (∼2200 BC) in Central Europe. Our results reveal that the current diversity and distribution of haplogroup H were largely established by the Mid Neolithic (∼4000 BC), but with substantial genetic contributions from subsequent pan-European cultures such as the Bell Beakers expanding out of Iberia in the Late Neolithic (∼2800 BC). Dated haplogroup H genomes allow us to reconstruct the recent evolutionary history of haplogroup H and reveal a mutation rate 45% higher than current estimates for human mitochondria.

Original language	English
Article number	1764
Number of pages	11
Journal	Nature Communications
Volume	4
Issue number	1764
DOIs	https://doi.org/10.1038/ncomms2656
Publication status	Published - 2013

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Brotherton, P., Haak, W., Templeton, J., Brandt, G., Soubrier, J., Adler, C., Richards, S., Der Sarkissian, C., Ganslmeier, R., Friederich, S., Dresely, V., van Oven, M., Kenyon, R., Van der Hoek, M., Korlach, J., Luong, K., Ho, S., Quintana-Murci, L., Behar, D., ... Cooper, A. (2013). Neolithic mitochondrial Haplogroup H genomes and the genetic origins of Europeans. Nature Communications, 4(1764), Article 1764. https://doi.org/10.1038/ncomms2656

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title = "Neolithic mitochondrial Haplogroup H genomes and the genetic origins of Europeans",

abstract = "Haplogroup H dominates present-day Western European mitochondrial DNA variability (>40%), yet was less common (∼19%) among Early Neolithic farmers (∼5450 BC) and virtually absent in Mesolithic hunter-gatherers. Here we investigate this major component of the maternal population history of modern Europeans and sequence 39 complete haplogroup H mitochondrial genomes from ancient human remains. We then compare this 'real-time' genetic data with cultural changes taking place between the Early Neolithic (∼5450 BC) and Bronze Age (∼2200 BC) in Central Europe. Our results reveal that the current diversity and distribution of haplogroup H were largely established by the Mid Neolithic (∼4000 BC), but with substantial genetic contributions from subsequent pan-European cultures such as the Bell Beakers expanding out of Iberia in the Late Neolithic (∼2800 BC). Dated haplogroup H genomes allow us to reconstruct the recent evolutionary history of haplogroup H and reveal a mutation rate 45% higher than current estimates for human mitochondria.",

author = "Paul Brotherton and Wolfgang Haak and Jennifer Templeton and Guido Brandt and Julien Soubrier and Christina Adler and S Richards and {Der Sarkissian}, Clio and Robert Ganslmeier and Susanne Friederich and Veit Dresely and {van Oven}, Mannis and Rosalie Kenyon and {Van der Hoek}, Mark and Jonas Korlach and Khai Luong and Simon Ho and Llu{\'i}s Quintana-Murci and Doron Behar and Harald Meller and Kurt Alt and Alan Cooper",

year = "2013",

doi = "10.1038/ncomms2656",

language = "English",

volume = "4",

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Brotherton, P, Haak, W, Templeton, J, Brandt, G, Soubrier, J, Adler, C, Richards, S, Der Sarkissian, C, Ganslmeier, R, Friederich, S, Dresely, V, van Oven, M, Kenyon, R, Van der Hoek, M, Korlach, J, Luong, K, Ho, S, Quintana-Murci, L, Behar, D, Meller, H, Alt, K & Cooper, A 2013, 'Neolithic mitochondrial Haplogroup H genomes and the genetic origins of Europeans', Nature Communications, vol. 4, no. 1764, 1764. https://doi.org/10.1038/ncomms2656

TY - JOUR

T1 - Neolithic mitochondrial Haplogroup H genomes and the genetic origins of Europeans

AU - Brotherton, Paul

AU - Haak, Wolfgang

AU - Templeton, Jennifer

AU - Brandt, Guido

AU - Soubrier, Julien

AU - Adler, Christina

AU - Richards, S

AU - Der Sarkissian, Clio

AU - Ganslmeier, Robert

AU - Friederich, Susanne

AU - Dresely, Veit

AU - van Oven, Mannis

AU - Kenyon, Rosalie

AU - Van der Hoek, Mark

AU - Korlach, Jonas

AU - Luong, Khai

AU - Ho, Simon

AU - Quintana-Murci, Lluís

AU - Behar, Doron

AU - Meller, Harald

AU - Alt, Kurt

AU - Cooper, Alan

PY - 2013

Y1 - 2013

N2 - Haplogroup H dominates present-day Western European mitochondrial DNA variability (>40%), yet was less common (∼19%) among Early Neolithic farmers (∼5450 BC) and virtually absent in Mesolithic hunter-gatherers. Here we investigate this major component of the maternal population history of modern Europeans and sequence 39 complete haplogroup H mitochondrial genomes from ancient human remains. We then compare this 'real-time' genetic data with cultural changes taking place between the Early Neolithic (∼5450 BC) and Bronze Age (∼2200 BC) in Central Europe. Our results reveal that the current diversity and distribution of haplogroup H were largely established by the Mid Neolithic (∼4000 BC), but with substantial genetic contributions from subsequent pan-European cultures such as the Bell Beakers expanding out of Iberia in the Late Neolithic (∼2800 BC). Dated haplogroup H genomes allow us to reconstruct the recent evolutionary history of haplogroup H and reveal a mutation rate 45% higher than current estimates for human mitochondria.

AB - Haplogroup H dominates present-day Western European mitochondrial DNA variability (>40%), yet was less common (∼19%) among Early Neolithic farmers (∼5450 BC) and virtually absent in Mesolithic hunter-gatherers. Here we investigate this major component of the maternal population history of modern Europeans and sequence 39 complete haplogroup H mitochondrial genomes from ancient human remains. We then compare this 'real-time' genetic data with cultural changes taking place between the Early Neolithic (∼5450 BC) and Bronze Age (∼2200 BC) in Central Europe. Our results reveal that the current diversity and distribution of haplogroup H were largely established by the Mid Neolithic (∼4000 BC), but with substantial genetic contributions from subsequent pan-European cultures such as the Bell Beakers expanding out of Iberia in the Late Neolithic (∼2800 BC). Dated haplogroup H genomes allow us to reconstruct the recent evolutionary history of haplogroup H and reveal a mutation rate 45% higher than current estimates for human mitochondria.

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U2 - 10.1038/ncomms2656

DO - 10.1038/ncomms2656

M3 - Article

SN - 2041-1723

VL - 4

JO - Nature Communications

JF - Nature Communications

IS - 1764

M1 - 1764

ER -

Neolithic mitochondrial Haplogroup H genomes and the genetic origins of Europeans

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