Abstract
The neurokinin 1 receptor (NK1R) induces Ca2+ flux in excitable cells. Here, Morelli et al. show that NK1R signaling in T cells promotes optimal Ca2+ flux triggered by TCR stimulation, which is necessary to sustain T cell survival and the efficient Th1- and Th17-based immunity that is relevant for immunotherapies based on pro-inflammatory neuropeptides.
Original language | English |
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Pages (from-to) | 3448-3465.e8 |
Number of pages | 27 |
Journal | Cell Reports |
Volume | 30 |
Issue number | 10 |
DOIs | |
Publication status | Published - 10 Mar 2020 |
Bibliographical note
This article is available under the Creative Commons CC-BY-NC-ND license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed.Keywords
- Ca flux
- G-protein-coupled receptors
- G
- hemokinin-1
- neurokinin-1 receptor
- substance P
- T cell activation
- T cell bias
- T cell receptor
- T cell survival