Neurokinin-1 Receptor Signaling Is Required for Efficient Ca2+ Flux in T-Cell-Receptor-Activated T Cells

Adrian E. Morelli, Tina L. Sumpter, Darling M. Rojas-Canales, Mohna Bandyopadhyay, Zhizhao Chen, Olga Tkacheva, William J. Shufesky, Callen T. Wallace, Simon C. Watkins, Alexandra Berger, Christopher J. Paige, Louis D. Falo, Adriana T. Larregina

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2 Citations (Scopus)

Abstract

The neurokinin 1 receptor (NK1R) induces Ca2+ flux in excitable cells. Here, Morelli et al. show that NK1R signaling in T cells promotes optimal Ca2+ flux triggered by TCR stimulation, which is necessary to sustain T cell survival and the efficient Th1- and Th17-based immunity that is relevant for immunotherapies based on pro-inflammatory neuropeptides.

Original languageEnglish
Pages (from-to)3448-3465.e8
Number of pages27
JournalCell Reports
Volume30
Issue number10
DOIs
Publication statusPublished - 10 Mar 2020

Bibliographical note

This article is available under the Creative Commons CC-BY-NC-ND license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed.

Keywords

  • Ca flux
  • G-protein-coupled receptors
  • G
  • hemokinin-1
  • neurokinin-1 receptor
  • substance P
  • T cell activation
  • T cell bias
  • T cell receptor
  • T cell survival

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  • Cite this

    Morelli, A. E., Sumpter, T. L., Rojas-Canales, D. M., Bandyopadhyay, M., Chen, Z., Tkacheva, O., Shufesky, W. J., Wallace, C. T., Watkins, S. C., Berger, A., Paige, C. J., Falo, L. D., & Larregina, A. T. (2020). Neurokinin-1 Receptor Signaling Is Required for Efficient Ca2+ Flux in T-Cell-Receptor-Activated T Cells. Cell Reports, 30(10), 3448-3465.e8. https://doi.org/10.1016/j.celrep.2020.02.054