Neurokinin-1 Receptor Signaling Is Required for Efficient Ca2+ Flux in T-Cell-Receptor-Activated T Cells

Adrian E. Morelli; Tina L. Sumpter; Darling M. Rojas-Canales; Mohna Bandyopadhyay; Zhizhao Chen; Olga Tkacheva; William J. Shufesky; Callen T. Wallace; Simon C. Watkins; Alexandra Berger; Christopher J. Paige; Louis D. Falo; Adriana T. Larregina

doi:10.1016/j.celrep.2020.02.054

Neurokinin-1 Receptor Signaling Is Required for Efficient Ca²⁺ Flux in T-Cell-Receptor-Activated T Cells

Adrian E. Morelli, Tina L. Sumpter, Darling M. Rojas-Canales, Mohna Bandyopadhyay, Zhizhao Chen, Olga Tkacheva, William J. Shufesky, Callen T. Wallace, Simon C. Watkins, Alexandra Berger, Christopher J. Paige, Louis D. Falo, Adriana T. Larregina

College of Medicine and Public Health

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

75 Downloads (Pure)

Abstract

The neurokinin 1 receptor (NK1R) induces Ca²⁺ flux in excitable cells. Here, Morelli et al. show that NK1R signaling in T cells promotes optimal Ca²⁺ flux triggered by TCR stimulation, which is necessary to sustain T cell survival and the efficient Th1- and Th17-based immunity that is relevant for immunotherapies based on pro-inflammatory neuropeptides.

Original language	English
Pages (from-to)	3448-3465.e8
Number of pages	27
Journal	Cell Reports
Volume	30
Issue number	10
DOIs	https://doi.org/10.1016/j.celrep.2020.02.054
Publication status	Published - 10 Mar 2020

Bibliographical note

This article is available under the Creative Commons CC-BY-NC-ND license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed.

Keywords

Ca flux
G-protein-coupled receptors
G
hemokinin-1
neurokinin-1 receptor
substance P
T cell activation
T cell bias
T cell receptor
T cell survival

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.celrep.2020.02.054Licence: CC BY-NC-ND

Morelli_Neurokinin_P2020Final published version, 5.51 MBLicence: CC BY-NC-ND

Cite this

Morelli, A. E., Sumpter, T. L., Rojas-Canales, D. M., Bandyopadhyay, M., Chen, Z., Tkacheva, O., Shufesky, W. J., Wallace, C. T., Watkins, S. C., Berger, A., Paige, C. J., Falo, L. D., & Larregina, A. T. (2020). Neurokinin-1 Receptor Signaling Is Required for Efficient Ca²⁺ Flux in T-Cell-Receptor-Activated T Cells. Cell Reports, 30(10), 3448-3465.e8. https://doi.org/10.1016/j.celrep.2020.02.054

@article{fc3783be53484aada3d13932fe820f96,

title = "Neurokinin-1 Receptor Signaling Is Required for Efficient Ca2+ Flux in T-Cell-Receptor-Activated T Cells",

abstract = "The neurokinin 1 receptor (NK1R) induces Ca2+ flux in excitable cells. Here, Morelli et al. show that NK1R signaling in T cells promotes optimal Ca2+ flux triggered by TCR stimulation, which is necessary to sustain T cell survival and the efficient Th1- and Th17-based immunity that is relevant for immunotherapies based on pro-inflammatory neuropeptides.",

keywords = "Ca flux, G-protein-coupled receptors, G, hemokinin-1, neurokinin-1 receptor, substance P, T cell activation, T cell bias, T cell receptor, T cell survival",

author = "Morelli, {Adrian E.} and Sumpter, {Tina L.} and Rojas-Canales, {Darling M.} and Mohna Bandyopadhyay and Zhizhao Chen and Olga Tkacheva and Shufesky, {William J.} and Wallace, {Callen T.} and Watkins, {Simon C.} and Alexandra Berger and Paige, {Christopher J.} and Falo, {Louis D.} and Larregina, {Adriana T.}",

note = "This article is available under the Creative Commons CC-BY-NC-ND license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed.",

year = "2020",

month = mar,

day = "10",

doi = "10.1016/j.celrep.2020.02.054",

language = "English",

volume = "30",

pages = "3448--3465.e8",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Cell Press",

number = "10",

}

Morelli, AE, Sumpter, TL, Rojas-Canales, DM, Bandyopadhyay, M, Chen, Z, Tkacheva, O, Shufesky, WJ, Wallace, CT, Watkins, SC, Berger, A, Paige, CJ, Falo, LD & Larregina, AT 2020, 'Neurokinin-1 Receptor Signaling Is Required for Efficient Ca²⁺ Flux in T-Cell-Receptor-Activated T Cells', Cell Reports, vol. 30, no. 10, pp. 3448-3465.e8. https://doi.org/10.1016/j.celrep.2020.02.054

TY - JOUR

T1 - Neurokinin-1 Receptor Signaling Is Required for Efficient Ca2+ Flux in T-Cell-Receptor-Activated T Cells

AU - Morelli, Adrian E.

AU - Sumpter, Tina L.

AU - Rojas-Canales, Darling M.

AU - Bandyopadhyay, Mohna

AU - Chen, Zhizhao

AU - Tkacheva, Olga

AU - Shufesky, William J.

AU - Wallace, Callen T.

AU - Watkins, Simon C.

AU - Berger, Alexandra

AU - Paige, Christopher J.

AU - Falo, Louis D.

AU - Larregina, Adriana T.

N1 - This article is available under the Creative Commons CC-BY-NC-ND license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed.

PY - 2020/3/10

Y1 - 2020/3/10

N2 - The neurokinin 1 receptor (NK1R) induces Ca2+ flux in excitable cells. Here, Morelli et al. show that NK1R signaling in T cells promotes optimal Ca2+ flux triggered by TCR stimulation, which is necessary to sustain T cell survival and the efficient Th1- and Th17-based immunity that is relevant for immunotherapies based on pro-inflammatory neuropeptides.

AB - The neurokinin 1 receptor (NK1R) induces Ca2+ flux in excitable cells. Here, Morelli et al. show that NK1R signaling in T cells promotes optimal Ca2+ flux triggered by TCR stimulation, which is necessary to sustain T cell survival and the efficient Th1- and Th17-based immunity that is relevant for immunotherapies based on pro-inflammatory neuropeptides.

KW - Ca flux

KW - G-protein-coupled receptors

KW - G

KW - hemokinin-1

KW - neurokinin-1 receptor

KW - substance P

KW - T cell activation

KW - T cell bias

KW - T cell receptor

KW - T cell survival

UR - http://www.scopus.com/inward/record.url?scp=85081013921&partnerID=8YFLogxK

U2 - 10.1016/j.celrep.2020.02.054

DO - 10.1016/j.celrep.2020.02.054

M3 - Article

C2 - 32160549

AN - SCOPUS:85081013921

SN - 2211-1247

VL - 30

SP - 3448-3465.e8

JO - Cell Reports

JF - Cell Reports

IS - 10

ER -