Neurons in the area postrema are the only catecholamine-synthesizing cells in the medulla or pons with projections to the rostral ventrolateral medulla (C1-area) in the rabbit

W. W. Blessing, S. C. Hedger, T. H. Joh, J. O. Willoughby

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    93 Citations (Scopus)

    Abstract

    We have identified, in the rabbit medulla and pons, neurons which project to the C1-region of the rostral ventrolateral medulla. By combining tyrosine hydroxylase immunohistochemistry with retrograde transport of Fluoro-Gold we determined whether any of the retrogradely labelled neurons synthesize catecholamines. The only doubly labelled cells were located in the area postrema. No other group of catecholamine-synthesizing neurons in either the medulla or the pons was found to project to the C1-area of the rostral ventrolateral medulla. Pharmacological agents which lower arterial pressure by stimulating adrenoceptors in the rostral ventrolateral medulla may act on receptors which are not innervated by catecholamine-synthesizing perikarya located outside the C1-region.

    Original languageEnglish
    Pages (from-to)336-340
    Number of pages5
    JournalBrain Research
    Volume419
    Issue number1-2
    DOIs
    Publication statusPublished - 1 Sep 1987

    Keywords

    • Area postrema
    • Fluoro-Gold
    • Noradrenergic neuron
    • Sympathoexcitatory neuron
    • Sympathoinhibitory neuron
    • Tyrosine hydroxylase immunohistochemistry

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