Neuropeptide Y-immunoreactive synapses in the intermediolateral cell column of rat and rabbit thoracic spinal cord

I. J. Llewellyn-Smith; J. B. Minson; D. A. Morilak; J. R. Oliver; J. P. Chalmers

doi:10.1016/0304-3940(90)90648-S

Neuropeptide Y-immunoreactive synapses in the intermediolateral cell column of rat and rabbit thoracic spinal cord

I. J. Llewellyn-Smith, J. B. Minson, D. A. Morilak, J. R. Oliver, J. P. Chalmers

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Abstract

Neuropeptide Y (NPY)-immunoreactive nerve fibers in the intermediolateral cell column of rat spinal cord segments T₂-T₃ and T₈-T₁₀ and rabbit segments T₃-T₆ were studied with light and electron microscopic immunocytochemistry. Plexuses of NPY-immunoreactive nerve fibers were found by light microscopy. NPY-positive synapses were present electron microscopically but non-immunoreactive synapses greatly outnumbered NPY-immunoreactive ones. In the lateral horn of rat T₉, 30% of the vesicle-containing NPY-positive axon profiles formed synapses, 95% of which were axodendritic. These synaptic connections may mediate the effects of brainstem NPY neurons on the activity of sympathetic preganglionic neurons.

Original language	English
Pages (from-to)	243-248
Number of pages	6
Journal	Neuroscience letters
Volume	108
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(90)90648-S
Publication status	Published - 22 Jan 1990

Keywords

Blood pressure
Immunocytochemistry
Intermediolateral cell column
Neuropeptide Y
Spinal cord
Ultrastructure

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AU - Llewellyn-Smith, I. J.

AU - Minson, J. B.

AU - Morilak, D. A.

AU - Oliver, J. R.

AU - Chalmers, J. P.

PY - 1990/1/22

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N2 - Neuropeptide Y (NPY)-immunoreactive nerve fibers in the intermediolateral cell column of rat spinal cord segments T2-T3 and T8-T10 and rabbit segments T3-T6 were studied with light and electron microscopic immunocytochemistry. Plexuses of NPY-immunoreactive nerve fibers were found by light microscopy. NPY-positive synapses were present electron microscopically but non-immunoreactive synapses greatly outnumbered NPY-immunoreactive ones. In the lateral horn of rat T9, 30% of the vesicle-containing NPY-positive axon profiles formed synapses, 95% of which were axodendritic. These synaptic connections may mediate the effects of brainstem NPY neurons on the activity of sympathetic preganglionic neurons.

AB - Neuropeptide Y (NPY)-immunoreactive nerve fibers in the intermediolateral cell column of rat spinal cord segments T2-T3 and T8-T10 and rabbit segments T3-T6 were studied with light and electron microscopic immunocytochemistry. Plexuses of NPY-immunoreactive nerve fibers were found by light microscopy. NPY-positive synapses were present electron microscopically but non-immunoreactive synapses greatly outnumbered NPY-immunoreactive ones. In the lateral horn of rat T9, 30% of the vesicle-containing NPY-positive axon profiles formed synapses, 95% of which were axodendritic. These synaptic connections may mediate the effects of brainstem NPY neurons on the activity of sympathetic preganglionic neurons.

KW - Blood pressure

KW - Immunocytochemistry

KW - Intermediolateral cell column

KW - Neuropeptide Y

KW - Spinal cord

KW - Ultrastructure

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Neuropeptide Y-immunoreactive synapses in the intermediolateral cell column of rat and rabbit thoracic spinal cord

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