Neuropeptide Y injected into the supraoptic nucleus causes secretion of vasopressin in the unanesthetized rat

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    Abstract

    Injection of neuropeptide Y (NPY, 0.01-1.0 nmol in 0.25 μl vehicle) into the supraoptic nucleus of unanesthetized rats increased plasma vasopressin, measured by radioimmunoassay, to a maximum of 90±18 ng/liter. Injections of vehicle or somatostatin did not increase plasma vasopressin, nor did injections of NPY into the amygdala. Double-labelling immunohistochemical studies demonstrated that fibers containing NPY-like immunoreactivity form a close association with vasopressin immunoreactive perikarya in the supraoptic nucleus. It appears that NPY may directly excite vasopressin-containing neurons causing secretion of vasopressin.

    Original languageEnglish
    Pages (from-to)17-22
    Number of pages6
    JournalNeuroscience letters
    Volume75
    Issue number1
    DOIs
    Publication statusPublished - 20 Mar 1987

    Keywords

    • Neuropeptide Y
    • Noradrenaline
    • Rat
    • Supraoptic nucleus
    • Vasopressin

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