Neuropeptide Y injected into the supraoptic nucleus causes secretion of vasopressin in the unanesthetized rat

J. O. Willoughby; W. W. Blessing

doi:10.1016/0304-3940(87)90068-1

Neuropeptide Y injected into the supraoptic nucleus causes secretion of vasopressin in the unanesthetized rat

J. O. Willoughby, W. W. Blessing

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Abstract

Injection of neuropeptide Y (NPY, 0.01-1.0 nmol in 0.25 μl vehicle) into the supraoptic nucleus of unanesthetized rats increased plasma vasopressin, measured by radioimmunoassay, to a maximum of 90±18 ng/liter. Injections of vehicle or somatostatin did not increase plasma vasopressin, nor did injections of NPY into the amygdala. Double-labelling immunohistochemical studies demonstrated that fibers containing NPY-like immunoreactivity form a close association with vasopressin immunoreactive perikarya in the supraoptic nucleus. It appears that NPY may directly excite vasopressin-containing neurons causing secretion of vasopressin.

Original language	English
Pages (from-to)	17-22
Number of pages	6
Journal	Neuroscience letters
Volume	75
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(87)90068-1
Publication status	Published - 20 Mar 1987

Keywords

Neuropeptide Y
Noradrenaline
Rat
Supraoptic nucleus
Vasopressin

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T1 - Neuropeptide Y injected into the supraoptic nucleus causes secretion of vasopressin in the unanesthetized rat

AU - Willoughby, J. O.

AU - Blessing, W. W.

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N2 - Injection of neuropeptide Y (NPY, 0.01-1.0 nmol in 0.25 μl vehicle) into the supraoptic nucleus of unanesthetized rats increased plasma vasopressin, measured by radioimmunoassay, to a maximum of 90±18 ng/liter. Injections of vehicle or somatostatin did not increase plasma vasopressin, nor did injections of NPY into the amygdala. Double-labelling immunohistochemical studies demonstrated that fibers containing NPY-like immunoreactivity form a close association with vasopressin immunoreactive perikarya in the supraoptic nucleus. It appears that NPY may directly excite vasopressin-containing neurons causing secretion of vasopressin.

AB - Injection of neuropeptide Y (NPY, 0.01-1.0 nmol in 0.25 μl vehicle) into the supraoptic nucleus of unanesthetized rats increased plasma vasopressin, measured by radioimmunoassay, to a maximum of 90±18 ng/liter. Injections of vehicle or somatostatin did not increase plasma vasopressin, nor did injections of NPY into the amygdala. Double-labelling immunohistochemical studies demonstrated that fibers containing NPY-like immunoreactivity form a close association with vasopressin immunoreactive perikarya in the supraoptic nucleus. It appears that NPY may directly excite vasopressin-containing neurons causing secretion of vasopressin.

KW - Neuropeptide Y

KW - Noradrenaline

KW - Rat

KW - Supraoptic nucleus

KW - Vasopressin

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Neuropeptide Y injected into the supraoptic nucleus causes secretion of vasopressin in the unanesthetized rat

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