Neurotrophic Therapy for ALS/MND

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Abstract

Neurotrophic factors have a large range of activities in the nervous system that consist of functions in development, plasticity, neurogenesis, disease, and injury. In the context of amyotrophic lateral sclerosis (ALS), it has long been hypothesized that lack of neurotrophic growth factors is one of the neurotoxic contributors to the disease that results in death of motor neurons. This has led to a considerable number of clinical trials undertaken involving neurotrophic therapy for ALS, although none have shown benefit. This chapter will review the cause and pathology of ALS and how neurotrophic factors relate to neurotoxicity in this disease. The treatments targeted at neurotoxicity and results of trials will be discussed, in particular neurotrophic factors. This will include glial cell-derived neurotrophic factor (GDNF), brain-derived growth factor (BDNF), neurotrophin-3 (NT-3), ciliary neurotrophic factor (CNTF), insulin-like growth factor (IGF), vascular endothelial cell growth factor (VEGF), fibroblast growth factor (FGF), and hepatocyte growth factor (HGF). Also highlighted is the potential for reexamining neurotrophic factors as treatments for ALS, including new delivery methods.
Original languageEnglish
Title of host publicationHandbook of Neurotoxicity
EditorsRichard M. Kostrzewa
Place of PublicationSwitzerland AF
PublisherSpringer
Number of pages37
ISBN (Electronic)978-3-030-71519-9
ISBN (Print)978-3-030-71519-9
DOIs
Publication statusE-pub ahead of print - 10 Nov 2021

Publication series

Name
PublisherSpringer-Verlag

Keywords

  • ALS and MND
  • Neurotrophic factor
  • Novel Treatments
  • BDNF
  • CNTF
  • FGF
  • GFNF
  • IGF
  • NGF
  • NT-3
  • NT-4
  • VEGF

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  • Biofluid Biomarkers of Amyotrophic Lateral Sclerosis

    Holdom, C., Steyn, F. J., Henderson, R. D., McCombe, P. A., Rogers, M-L. & Ngo, S. T., 2022, Neuromethods: Towards Translating Research to Clinical Practice. Peplow, P. V., Martinez, B. & Gennarelli, T. A. (eds.). New York: Springer , p. 263-306 44 p. (Neuromethods; vol. 173).

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

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