Neurotrophin-3 and TrkC-immunoreactive neurons in rat dorsal root ganglia correlate by distribution and morphology

Colin Chen, Xin Fu Zhou, Robert A. Rush

    Research output: Contribution to journalArticle

    16 Citations (Scopus)

    Abstract

    Previous studies have shown that a subpopulation of large dorsal root ganglion neurons contains neurotrophin-3 (NT3)-like immunoreactivity. It is not known, however, whether these NT3 immunoreactive neurons also express the high affinity receptor for NT3, trkC. In the present study, the distribution and morphology of trkC immunoreactive neurons have been correlated with those of NT3 immunoreactive neurons in the dorsal root ganglia. Size and segmental distributions of both antigens indicate that they are present in the same group of large sensory neurons. Almost twice the number of these neurons are present in the cervical and lumbar spinal ganglia than in the thoracic. Co- localization study indicates that 94% of NT3 immunoreactive neurons express trkC. Our findings support the proposal that NT3 in these neurons is derived from their peripheral targets rather than synthesized in situ.

    Original languageEnglish
    Pages (from-to)809-814
    Number of pages6
    JournalNeurochemical Research
    Volume21
    Issue number7
    DOIs
    Publication statusPublished - Jul 1996

    Keywords

    • dorsal root ganglion
    • immunohistochemistry
    • Neurotrophin 3
    • sensory neuron
    • TrkC

    Fingerprint Dive into the research topics of 'Neurotrophin-3 and TrkC-immunoreactive neurons in rat dorsal root ganglia correlate by distribution and morphology'. Together they form a unique fingerprint.

    Cite this