TY - JOUR
T1 - Neutrophil to lymphocyte ratio and clinical outcomes in COPD: recent evidence and future perspectives
AU - Paliogiannis, Panagiotis
AU - Fois, Alessandro
AU - Sotgia, Salvatore
AU - Mangoni, Arduino
AU - Zinellu, Elisabetta
AU - Pirina, Pietro
AU - Negri, Silvia
AU - Carru, Ciriaco
AU - Zinellu, Angelo
PY - 2018/3/31
Y1 - 2018/3/31
N2 - Chronic obstructive pulmonary disease (COPD) is a disabling condition that is characterised by poorly reversible airflow limitation and inflammation. Acute exacerbations of COPD are a common cause of hospitalisation and death among COPD patients. Several biochemical markers have been studied as outcome predictors in COPD; however, their measurement often requires significant time and resources. Relatively simple biomarkers of inflammation calculated from routine complete blood count tests, such as the neutrophil to lymphocyte ratio (NLR), might also predict COPD progression and outcomes. This review discusses the available evidence from studies investigating the associations between the NLR, COPD exacerbations and death in this patient group.
AB - Chronic obstructive pulmonary disease (COPD) is a disabling condition that is characterised by poorly reversible airflow limitation and inflammation. Acute exacerbations of COPD are a common cause of hospitalisation and death among COPD patients. Several biochemical markers have been studied as outcome predictors in COPD; however, their measurement often requires significant time and resources. Relatively simple biomarkers of inflammation calculated from routine complete blood count tests, such as the neutrophil to lymphocyte ratio (NLR), might also predict COPD progression and outcomes. This review discusses the available evidence from studies investigating the associations between the NLR, COPD exacerbations and death in this patient group.
UR - http://www.scopus.com/inward/record.url?scp=85041920483&partnerID=8YFLogxK
U2 - 10.1183/16000617.0113-2017
DO - 10.1183/16000617.0113-2017
M3 - Article
SN - 1600-0617
VL - 27
JO - European Respiratory Review
JF - European Respiratory Review
IS - 147
M1 - 170113
ER -