Neutrophil to lymphocyte ratio and clinical outcomes in COPD: recent evidence and future perspectives

Panagiotis Paliogiannis, Alessandro Fois, Salvatore Sotgia, Arduino Mangoni, Elisabetta Zinellu, Pietro Pirina, Silvia Negri, Ciriaco Carru, Angelo Zinellu

    Research output: Contribution to journalArticlepeer-review

    47 Citations (Scopus)

    Abstract

    Chronic obstructive pulmonary disease (COPD) is a disabling condition that is characterised by poorly reversible airflow limitation and inflammation. Acute exacerbations of COPD are a common cause of hospitalisation and death among COPD patients. Several biochemical markers have been studied as outcome predictors in COPD; however, their measurement often requires significant time and resources. Relatively simple biomarkers of inflammation calculated from routine complete blood count tests, such as the neutrophil to lymphocyte ratio (NLR), might also predict COPD progression and outcomes. This review discusses the available evidence from studies investigating the associations between the NLR, COPD exacerbations and death in this patient group.

    Original languageEnglish
    Article number170113
    Number of pages10
    JournalEuropean Respiratory Review
    Volume27
    Issue number147
    DOIs
    Publication statusPublished - 31 Mar 2018

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