Neutrophil to lymphocyte ratio and muscular invasion in early-stage bladder cancer: a meta-analysis

Massimo Madonia, Panagiotis Paliogiannis, Tatiana Solinas, Arduino Aleksander Mangoni, Ciriaco Carru, Angelo Zinellu

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Background: Bladder cancer is the ninth most common cancer worldwide. In its early stages, invasion of the muscle layer of the bladder is the major determinant for cystectomy. The aim of this meta-analysis was to evaluate the potential role of the neutrophil to lymphocyte ratio (NLR) in predicting muscular invasion in early-stage bladder cancer. Methods: A systematic literature search was conducted in Medline, Pubmed, Scopus and Clinicaltrials.gov databases for English language articles published in the last decade. Results: Five studies fulfilling the eligibility criteria were identified (1,612 participants, 1,217 with NMIBC and 395 with MIBC). Pooled results showed that NLR values were significantly higher in patients with MIBC (SMD: 0.45, 95% CI: 0.18-0.73; p=0.001). Conclusions: NLR is significantly higher in patients with MIBC in comparison to those with NMIBC. This simple, widely available and relatively inexpensive parameter might be useful for risk stratification in patients with early-stage BC.

Original languageEnglish
Pages (from-to)65-71
Number of pages7
JournalEuropean Journal of Oncology
Volume23
Issue number2
Publication statusPublished - 12 Dec 2018

Keywords

  • Bladder
  • Cancer
  • Muscle invasion
  • NLR
  • Urothelial

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