New antimalarial norterpene cyclic peroxides from Xisha Islands sponge Diacarnus megaspinorhabdosa

Fan Yang; Ru Ping Wang; Bin Xu; Hao Bing Yu; Guo Yi Ma; Guang Fei Wang; Shu Wen Dai; Wei Zhang; Wei Hua Jiao; Shao Jiang Song; Hou Wen Lin

doi:10.1016/j.bmcl.2016.02.070

New antimalarial norterpene cyclic peroxides from Xisha Islands sponge Diacarnus megaspinorhabdosa

Fan Yang, Ru Ping Wang, Bin Xu, Hao Bing Yu, Guo Yi Ma, Guang Fei Wang, Shu Wen Dai, Wei Zhang, Wei Hua Jiao, Shao Jiang Song, Hou Wen Lin

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Four new norterpene cyclic peroxides (1-4), together with three known norterpene cyclic peroxides were isolated from the Xisha Islands Sponge Diacarnus megaspinorhabdosa. Their structures were elucidated on the basis of spectroscopic analyses and comparison with the related model compounds. The compounds (1-7) were evaluated for the inhibitory activity against the malaria parasite Plasmodium falciparum, all of them showed significant antimalarial activity with IC₅₀ values in the range of 1.6-8.6 μM.

Original language	English
Pages (from-to)	2084-2087
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	26
Issue number	8
DOIs	https://doi.org/10.1016/j.bmcl.2016.02.070
Publication status	Published - 15 Apr 2016
Externally published	Yes

Keywords

Antimalarial
Diacarnus megaspinorhabdosa
Norterpene cyclic peroxide

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@article{bd854645acc142c3a5bcc19c8053f846,

title = "New antimalarial norterpene cyclic peroxides from Xisha Islands sponge Diacarnus megaspinorhabdosa",

abstract = "Four new norterpene cyclic peroxides (1-4), together with three known norterpene cyclic peroxides were isolated from the Xisha Islands Sponge Diacarnus megaspinorhabdosa. Their structures were elucidated on the basis of spectroscopic analyses and comparison with the related model compounds. The compounds (1-7) were evaluated for the inhibitory activity against the malaria parasite Plasmodium falciparum, all of them showed significant antimalarial activity with IC50 values in the range of 1.6-8.6 μM.",

keywords = "Antimalarial, Diacarnus megaspinorhabdosa, Norterpene cyclic peroxide",

author = "Fan Yang and Wang, {Ru Ping} and Bin Xu and Yu, {Hao Bing} and Ma, {Guo Yi} and Wang, {Guang Fei} and Dai, {Shu Wen} and Wei Zhang and Jiao, {Wei Hua} and Song, {Shao Jiang} and Lin, {Hou Wen}",

year = "2016",

month = apr,

day = "15",

doi = "10.1016/j.bmcl.2016.02.070",

language = "English",

volume = "26",

pages = "2084--2087",

journal = "Bioorganic & Medicinal Chemistry Letters",

issn = "0960-894X",

number = "8",

}

New antimalarial norterpene cyclic peroxides from Xisha Islands sponge Diacarnus megaspinorhabdosa. / Yang, Fan; Wang, Ru Ping; Xu, Bin; Yu, Hao Bing; Ma, Guo Yi; Wang, Guang Fei; Dai, Shu Wen; Zhang, Wei; Jiao, Wei Hua; Song, Shao Jiang; Lin, Hou Wen.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 26, No. 8, 15.04.2016, p. 2084-2087.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - New antimalarial norterpene cyclic peroxides from Xisha Islands sponge Diacarnus megaspinorhabdosa

AU - Yang, Fan

AU - Wang, Ru Ping

AU - Xu, Bin

AU - Yu, Hao Bing

AU - Ma, Guo Yi

AU - Wang, Guang Fei

AU - Dai, Shu Wen

AU - Zhang, Wei

AU - Jiao, Wei Hua

AU - Song, Shao Jiang

AU - Lin, Hou Wen

PY - 2016/4/15

Y1 - 2016/4/15

N2 - Four new norterpene cyclic peroxides (1-4), together with three known norterpene cyclic peroxides were isolated from the Xisha Islands Sponge Diacarnus megaspinorhabdosa. Their structures were elucidated on the basis of spectroscopic analyses and comparison with the related model compounds. The compounds (1-7) were evaluated for the inhibitory activity against the malaria parasite Plasmodium falciparum, all of them showed significant antimalarial activity with IC50 values in the range of 1.6-8.6 μM.

AB - Four new norterpene cyclic peroxides (1-4), together with three known norterpene cyclic peroxides were isolated from the Xisha Islands Sponge Diacarnus megaspinorhabdosa. Their structures were elucidated on the basis of spectroscopic analyses and comparison with the related model compounds. The compounds (1-7) were evaluated for the inhibitory activity against the malaria parasite Plasmodium falciparum, all of them showed significant antimalarial activity with IC50 values in the range of 1.6-8.6 μM.

KW - Antimalarial

KW - Diacarnus megaspinorhabdosa

KW - Norterpene cyclic peroxide

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DO - 10.1016/j.bmcl.2016.02.070

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SP - 2084

EP - 2087

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

SN - 0960-894X

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