Abstract
Four new norterpene cyclic peroxides (1-4), together with three known norterpene cyclic peroxides were isolated from the Xisha Islands Sponge Diacarnus megaspinorhabdosa. Their structures were elucidated on the basis of spectroscopic analyses and comparison with the related model compounds. The compounds (1-7) were evaluated for the inhibitory activity against the malaria parasite Plasmodium falciparum, all of them showed significant antimalarial activity with IC50 values in the range of 1.6-8.6 μM.
Original language | English |
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Pages (from-to) | 2084-2087 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 26 |
Issue number | 8 |
DOIs | |
Publication status | Published - 15 Apr 2016 |
Externally published | Yes |
Keywords
- Antimalarial
- Diacarnus megaspinorhabdosa
- Norterpene cyclic peroxide