New antimalarial norterpene cyclic peroxides from Xisha Islands sponge Diacarnus megaspinorhabdosa

Fan Yang, Ru Ping Wang, Bin Xu, Hao Bing Yu, Guo Yi Ma, Guang Fei Wang, Shu Wen Dai, Wei Zhang, Wei Hua Jiao, Shao Jiang Song, Hou Wen Lin

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Four new norterpene cyclic peroxides (1-4), together with three known norterpene cyclic peroxides were isolated from the Xisha Islands Sponge Diacarnus megaspinorhabdosa. Their structures were elucidated on the basis of spectroscopic analyses and comparison with the related model compounds. The compounds (1-7) were evaluated for the inhibitory activity against the malaria parasite Plasmodium falciparum, all of them showed significant antimalarial activity with IC50 values in the range of 1.6-8.6 μM.

Original languageEnglish
Pages (from-to)2084-2087
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume26
Issue number8
DOIs
Publication statusPublished - 15 Apr 2016
Externally publishedYes

Keywords

  • Antimalarial
  • Diacarnus megaspinorhabdosa
  • Norterpene cyclic peroxide

Fingerprint Dive into the research topics of 'New antimalarial norterpene cyclic peroxides from Xisha Islands sponge Diacarnus megaspinorhabdosa'. Together they form a unique fingerprint.

  • Cite this

    Yang, F., Wang, R. P., Xu, B., Yu, H. B., Ma, G. Y., Wang, G. F., Dai, S. W., Zhang, W., Jiao, W. H., Song, S. J., & Lin, H. W. (2016). New antimalarial norterpene cyclic peroxides from Xisha Islands sponge Diacarnus megaspinorhabdosa. Bioorganic and Medicinal Chemistry Letters, 26(8), 2084-2087. https://doi.org/10.1016/j.bmcl.2016.02.070