New diterpene alkaloids from the marine sponge Agelas mauritiana

Li-Li Hong, Jia-Bao Sun, Fan Yang, Man Liu, Jie Tang, Fan Sun, Wei-Hua Jiao, Shu-Ping Wang, Wei Zhang, Hou-Wen Lin

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    11 Citations (Scopus)

    Abstract

    Chemical investigation of an ethanol extract of the sponge Agelas mauritiana led to the isolation and characterization of five new diterpene alkaloids, namely, (-)-8′-oxo-agelasine B (1), (+)-agelasine B (2), (+)-8′-oxo-agelasine C (3), agelasine V (4), and (+)-8′-oxo-agelasine E (5), along with two known compounds, (-)-8′-oxo-agelasine D (6), and agelasine D (7). The structures of these compounds were determined by interpretation of spectroscopic data and comparison with literature properties. Compounds 1 and 3-5 are the second example of 8′-oxo-agelasine analogs. Compounds 2 and 7 not only exhibited moderate cytotoxicity toward the cancer cell lines PC9, A549, HepG2, MCF-7, and U937 with IC50 values of 4.49-14.41 μM, but also showed potent antibacterial activities against a panel of methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates with MIC90 values of 1-8 μg mL-1.

    Original languageEnglish
    Pages (from-to)23970-23976
    Number of pages7
    JournalRSC Advances
    Volume7
    Issue number39
    DOIs
    Publication statusPublished - 2017

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  • Cite this

    Hong, L-L., Sun, J-B., Yang, F., Liu, M., Tang, J., Sun, F., Jiao, W-H., Wang, S-P., Zhang, W., & Lin, H-W. (2017). New diterpene alkaloids from the marine sponge Agelas mauritiana. RSC Advances, 7(39), 23970-23976. https://doi.org/10.1039/c7ra02547e