New Opportunities for Targeting the Androgen Receptor in Prostate Cancer

Margaret M. Centenera, Luke A. Selth, Esmaeil Ebrahimie, Lisa M. Butler, Wayne D. Tilley

Research output: Contribution to journalReview article

Abstract

Recent genomic analyses of metastatic prostate cancer have provided important insight into adaptive changes in androgen receptor (AR) signaling that underpin resistance to androgen deprivation therapies. Novel strategies are required to circumvent these AR-mediated resistance mechanisms and thereby improve prostate cancer survival. In this review, we present a summary of AR structure and function and discuss mechanisms of AR-mediated therapy resistance that represent important areas of focus for the development of new therapies.

Original languageEnglish
Article numbera030478
JournalCold Spring Harbor perspectives in medicine
Volume8
Issue number12
Early online date12 Mar 2018
DOIs
Publication statusPublished - Jan 2020
Externally publishedYes

Keywords

  • prostate cancer
  • Androgen Receptor

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