New Opportunities for Targeting the Androgen Receptor in Prostate Cancer

Margaret M. Centenera; Luke A. Selth; Esmaeil Ebrahimie; Lisa M. Butler; Wayne D. Tilley

doi:10.1101/cshperspect.a030478

New Opportunities for Targeting the Androgen Receptor in Prostate Cancer

Margaret M. Centenera, Luke A. Selth, Esmaeil Ebrahimie, Lisa M. Butler, Wayne D. Tilley

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Recent genomic analyses of metastatic prostate cancer have provided important insight into adaptive changes in androgen receptor (AR) signaling that underpin resistance to androgen deprivation therapies. Novel strategies are required to circumvent these AR-mediated resistance mechanisms and thereby improve prostate cancer survival. In this review, we present a summary of AR structure and function and discuss mechanisms of AR-mediated therapy resistance that represent important areas of focus for the development of new therapies.

Original language	English
Article number	a030478
Journal	Cold Spring Harbor perspectives in medicine
Volume	8
Issue number	12
Early online date	12 Mar 2018
DOIs	https://doi.org/10.1101/cshperspect.a030478
Publication status	Published - 3 Dec 2018
Externally published	Yes

Keywords

prostate cancer
Androgen Receptor

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1101/cshperspect.a030478Licence: In Copyright

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abstract = "Recent genomic analyses of metastatic prostate cancer have provided important insight into adaptive changes in androgen receptor (AR) signaling that underpin resistance to androgen deprivation therapies. Novel strategies are required to circumvent these AR-mediated resistance mechanisms and thereby improve prostate cancer survival. In this review, we present a summary of AR structure and function and discuss mechanisms of AR-mediated therapy resistance that represent important areas of focus for the development of new therapies.",

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AU - Centenera, Margaret M.

AU - Selth, Luke A.

AU - Ebrahimie, Esmaeil

AU - Butler, Lisa M.

AU - Tilley, Wayne D.

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AB - Recent genomic analyses of metastatic prostate cancer have provided important insight into adaptive changes in androgen receptor (AR) signaling that underpin resistance to androgen deprivation therapies. Novel strategies are required to circumvent these AR-mediated resistance mechanisms and thereby improve prostate cancer survival. In this review, we present a summary of AR structure and function and discuss mechanisms of AR-mediated therapy resistance that represent important areas of focus for the development of new therapies.

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KW - Androgen Receptor

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UR - http://purl.org/au-research/grants/ARC/FT130101004

UR - http://purl.org/au-research/grants/NHMRC/1083961

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New Opportunities for Targeting the Androgen Receptor in Prostate Cancer

Abstract

Keywords

UN SDGs

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