New Opportunities for Targeting the Androgen Receptor in Prostate Cancer

Margaret M. Centenera, Luke A. Selth, Esmaeil Ebrahimie, Lisa M. Butler, Wayne D. Tilley

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Recent genomic analyses of metastatic prostate cancer have provided important insight into adaptive changes in androgen receptor (AR) signaling that underpin resistance to androgen deprivation therapies. Novel strategies are required to circumvent these AR-mediated resistance mechanisms and thereby improve prostate cancer survival. In this review, we present a summary of AR structure and function and discuss mechanisms of AR-mediated therapy resistance that represent important areas of focus for the development of new therapies.

Original languageEnglish
Article numbera030478
JournalCold Spring Harbor perspectives in medicine
Issue number12
Early online date12 Mar 2018
Publication statusPublished - 3 Dec 2018
Externally publishedYes


  • prostate cancer
  • Androgen Receptor


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