Newly identified structures of trace-amine associated receptor-1 (TAAR1) will aid discovery of next generation neuropsychiatric drugs

Research output: Contribution to journalComment/debate

Abstract

The trace-amine associated receptor-1 (TAAR1) is a member of the G-protein coupled receptor (GPCR) receptor family and is widely distributed across the brain and gastrointestinal system and functions in a variety of neuronal processes. A range of endogenous trace amines (TA) activate TAAR1 signalling pathways through G protein subtypes. Several neuropsychiatric disorders, including schizophrenia, depression, drug addiction, attention deficit hyperactive disorder (ADHD) and metabolic disorders are associated with TAAR1. An emerging new class of antipsychotic agents, TAAR1 agonists, show promise for treating schizophrenia (Ulotaront – US FDA Breakthrough therapy status) and other neuropsychiatric conditions...
Original languageEnglish
Number of pages4
JournalMOLECULAR PSYCHIATRY
Early online date7 Feb 2024
DOIs
Publication statusE-pub ahead of print - 7 Feb 2024

Keywords

  • Drug discovery
  • Neuroscience
  • Schizophrenia

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