Nitric oxide-releasing porous silicon nanoparticles

Morteza Hasanzadeh Kafshgari, Alex Cavallaro, Bahman Delalat, Frances J. Harding, Steven J.P. McInnes, Ermei Mäkilä, Jarno Salonen, Krasimir Vasilev, Nicolas H. Voelcker

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

In this study, the ability of porous silicon nanoparticles (PSi NPs) to entrap and deliver nitric oxide (NO) as an effective antibacterial agent is tested against different Gram-positive and Gram-negative bacteria. NO was entrapped inside PSi NPs functionalized by means of the thermal hydrocarbonization (THC) process. Subsequent reduction of nitrite in the presence of d-glucose led to the production of large NO payloads without reducing the biocompatibility of the PSi NPs with mammalian cells. The resulting PSi NPs demonstrated sustained release of NO and showed remarkable antibacterial efficiency and anti-biofilm-forming properties. These results will set the stage to develop antimicrobial nanoparticle formulations for applications in chronic wound treatment.

Original languageEnglish
Article number333
Number of pages9
JournalNanoscale Research Letters
Volume9
Issue number1
DOIs
Publication statusPublished - 4 Jul 2014
Externally publishedYes

Keywords

  • Antibacterial
  • Nitric oxide
  • Porous silicon nanoparticles

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