Nitric oxide-releasing porous silicon nanoparticles

Morteza Hasanzadeh Kafshgari; Alex Cavallaro; Bahman Delalat; Frances J. Harding; Steven J.P. McInnes; Ermei Mäkilä; Jarno Salonen; Krasimir Vasilev; Nicolas H. Voelcker

doi:10.1186/1556-276X-9-333

Nitric oxide-releasing porous silicon nanoparticles

Morteza Hasanzadeh Kafshgari, Alex Cavallaro, Bahman Delalat, Frances J. Harding, Steven J.P. McInnes, Ermei Mäkilä, Jarno Salonen, Krasimir Vasilev, Nicolas H. Voelcker

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

In this study, the ability of porous silicon nanoparticles (PSi NPs) to entrap and deliver nitric oxide (NO) as an effective antibacterial agent is tested against different Gram-positive and Gram-negative bacteria. NO was entrapped inside PSi NPs functionalized by means of the thermal hydrocarbonization (THC) process. Subsequent reduction of nitrite in the presence of d-glucose led to the production of large NO payloads without reducing the biocompatibility of the PSi NPs with mammalian cells. The resulting PSi NPs demonstrated sustained release of NO and showed remarkable antibacterial efficiency and anti-biofilm-forming properties. These results will set the stage to develop antimicrobial nanoparticle formulations for applications in chronic wound treatment.

Original language	English
Article number	333
Number of pages	9
Journal	Nanoscale Research Letters
Volume	9
Issue number	1
DOIs	https://doi.org/10.1186/1556-276X-9-333
Publication status	Published - 4 Jul 2014
Externally published	Yes

Keywords

Antibacterial
Nitric oxide
Porous silicon nanoparticles

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10.1186/1556-276X-9-333Licence: CC BY

Kafshgari_Nitric_P2014Final published version, 1.3 MBLicence: CC BY

Cite this

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title = "Nitric oxide-releasing porous silicon nanoparticles",

abstract = "In this study, the ability of porous silicon nanoparticles (PSi NPs) to entrap and deliver nitric oxide (NO) as an effective antibacterial agent is tested against different Gram-positive and Gram-negative bacteria. NO was entrapped inside PSi NPs functionalized by means of the thermal hydrocarbonization (THC) process. Subsequent reduction of nitrite in the presence of d-glucose led to the production of large NO payloads without reducing the biocompatibility of the PSi NPs with mammalian cells. The resulting PSi NPs demonstrated sustained release of NO and showed remarkable antibacterial efficiency and anti-biofilm-forming properties. These results will set the stage to develop antimicrobial nanoparticle formulations for applications in chronic wound treatment.",

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AU - Kafshgari, Morteza Hasanzadeh

AU - Cavallaro, Alex

AU - Delalat, Bahman

AU - Harding, Frances J.

AU - McInnes, Steven J.P.

AU - Mäkilä, Ermei

AU - Salonen, Jarno

AU - Vasilev, Krasimir

AU - Voelcker, Nicolas H.

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N2 - In this study, the ability of porous silicon nanoparticles (PSi NPs) to entrap and deliver nitric oxide (NO) as an effective antibacterial agent is tested against different Gram-positive and Gram-negative bacteria. NO was entrapped inside PSi NPs functionalized by means of the thermal hydrocarbonization (THC) process. Subsequent reduction of nitrite in the presence of d-glucose led to the production of large NO payloads without reducing the biocompatibility of the PSi NPs with mammalian cells. The resulting PSi NPs demonstrated sustained release of NO and showed remarkable antibacterial efficiency and anti-biofilm-forming properties. These results will set the stage to develop antimicrobial nanoparticle formulations for applications in chronic wound treatment.

AB - In this study, the ability of porous silicon nanoparticles (PSi NPs) to entrap and deliver nitric oxide (NO) as an effective antibacterial agent is tested against different Gram-positive and Gram-negative bacteria. NO was entrapped inside PSi NPs functionalized by means of the thermal hydrocarbonization (THC) process. Subsequent reduction of nitrite in the presence of d-glucose led to the production of large NO payloads without reducing the biocompatibility of the PSi NPs with mammalian cells. The resulting PSi NPs demonstrated sustained release of NO and showed remarkable antibacterial efficiency and anti-biofilm-forming properties. These results will set the stage to develop antimicrobial nanoparticle formulations for applications in chronic wound treatment.

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KW - Nitric oxide

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Nitric oxide-releasing porous silicon nanoparticles

Abstract

Keywords

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