Abstract
Introduction
In this chapter we describe some of the molecular biology and the inheritance and interpretation models relevant to the forensic analysis of non-autosomal markers. Specifically we will discuss the DNA profiling of mitochondrial DNA (mtDNA) and the two gonosomes; the X and Y chromosomes. Since the first edition of this book it has become apparent that one of the crucial aspects of Y chromosome typing is that it is often used when autosomal typing has failed. Because of this it is often applied to low template, mixed or degraded samples.
In this chapter we describe some of the molecular biology and the inheritance and interpretation models relevant to the forensic analysis of non-autosomal markers. Specifically we will discuss the DNA profiling of mitochondrial DNA (mtDNA) and the two gonosomes; the X and Y chromosomes. Since the first edition of this book it has become apparent that one of the crucial aspects of Y chromosome typing is that it is often used when autosomal typing has failed. Because of this it is often applied to low template, mixed or degraded samples.
| Original language | English |
|---|---|
| Title of host publication | Forensic DNA Evidence Interpretation |
| Editors | John S. Buckleton, Jo-Anne Bright, Duncan Taylor |
| Publisher | CRC Press |
| Chapter | 10 |
| Pages | 315-352 |
| Number of pages | 38 |
| Edition | Second edition |
| ISBN (Electronic) | 9781482258929 |
| ISBN (Print) | 9781482258899 |
| Publication status | Published - 2016 |
| Externally published | Yes |
Keywords
- DNA casework
- Peter Gill
- DNA analysis
- Interpretation of test results
- DNA frequencies
- LCN (ultra trace) analysis
- Non-autosomal (mito, X, and Y) DNA analysis