Non convulsive spike-wave discharges do not induce Fos in cerebro-cortical neurons

John O. Willoughby; Lorraine Mackenzie; Jennifer J. Hiscock; Stephen Sagar

doi:10.1016/0169-328X(93)90186-S

Non convulsive spike-wave discharges do not induce Fos in cerebro-cortical neurons

John O. Willoughby, Lorraine Mackenzie, Jennifer J. Hiscock, Stephen Sagar

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Abstract

Immunohistochemical localisation of Fos was used as a marker of neuronal activity to demonstrate neurons active during non-convulsive spike-wave epilepsy. Fos-positive neurons in cortex and several subcortical areas were counted. In undisturbed animals Fos counts were not related to spike-wave in any region. With the electroencephalographic (EEG) recording procedure, Fos induction occurred in all regions, even after habituation. However, in central cortex, counts were found to be inversely related to spike-wave duration. This suggests that neuronal activity is not increased during spike-wave and that the central cortex in these animals is less responsive to arousal than in non-epileptic animals.

Original language	English
Pages (from-to)	178-180
Number of pages	3
Journal	Molecular Brain Research
Volume	18
Issue number	1-2
DOIs	https://doi.org/10.1016/0169-328X(93)90186-S
Publication status	Published - Apr 1993

Keywords

Absence epilepsy
Animal model
Arousal
Cerebral cortex
Fos immunohistochemistry
Spike-wave

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title = "Non convulsive spike-wave discharges do not induce Fos in cerebro-cortical neurons",

abstract = "Immunohistochemical localisation of Fos was used as a marker of neuronal activity to demonstrate neurons active during non-convulsive spike-wave epilepsy. Fos-positive neurons in cortex and several subcortical areas were counted. In undisturbed animals Fos counts were not related to spike-wave in any region. With the electroencephalographic (EEG) recording procedure, Fos induction occurred in all regions, even after habituation. However, in central cortex, counts were found to be inversely related to spike-wave duration. This suggests that neuronal activity is not increased during spike-wave and that the central cortex in these animals is less responsive to arousal than in non-epileptic animals.",

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T1 - Non convulsive spike-wave discharges do not induce Fos in cerebro-cortical neurons

AU - Willoughby, John O.

AU - Mackenzie, Lorraine

AU - Hiscock, Jennifer J.

AU - Sagar, Stephen

PY - 1993/4

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N2 - Immunohistochemical localisation of Fos was used as a marker of neuronal activity to demonstrate neurons active during non-convulsive spike-wave epilepsy. Fos-positive neurons in cortex and several subcortical areas were counted. In undisturbed animals Fos counts were not related to spike-wave in any region. With the electroencephalographic (EEG) recording procedure, Fos induction occurred in all regions, even after habituation. However, in central cortex, counts were found to be inversely related to spike-wave duration. This suggests that neuronal activity is not increased during spike-wave and that the central cortex in these animals is less responsive to arousal than in non-epileptic animals.

AB - Immunohistochemical localisation of Fos was used as a marker of neuronal activity to demonstrate neurons active during non-convulsive spike-wave epilepsy. Fos-positive neurons in cortex and several subcortical areas were counted. In undisturbed animals Fos counts were not related to spike-wave in any region. With the electroencephalographic (EEG) recording procedure, Fos induction occurred in all regions, even after habituation. However, in central cortex, counts were found to be inversely related to spike-wave duration. This suggests that neuronal activity is not increased during spike-wave and that the central cortex in these animals is less responsive to arousal than in non-epileptic animals.

KW - Absence epilepsy

KW - Animal model

KW - Arousal

KW - Cerebral cortex

KW - Fos immunohistochemistry

KW - Spike-wave

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Non convulsive spike-wave discharges do not induce Fos in cerebro-cortical neurons

Abstract

Keywords

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