Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer’s disease

Xavier Hadoux, Flora Hui, Jeremiah K.H. Lim, Colin L. Masters, Alice Pébay, Sophie Chevalier, Jason Ha, Samantha Loi, Christopher J. Fowler, Christopher Rowe, Victor L. Villemagne, Edward N. Taylor, Christopher Fluke, Jean Paul Soucy, Frédéric Lesage, Jean Philippe Sylvestre, Pedro Rosa-Neto, Sulantha Mathotaarachchi, Serge Gauthier, Ziad S. NasreddineJean Daniel Arbour, Marc André Rhéaume, Sylvain Beaulieu, Mohamed Dirani, Christine T.O. Nguyen, Bang V. Bui, Robert Williamson, Jonathan G. Crowston, Peter van Wijngaarden

    Research output: Contribution to journalArticlepeer-review

    85 Citations (Scopus)
    3 Downloads (Pure)


    Studies of rodent models of Alzheimer’s disease (AD) and of human tissues suggest that the retinal changes that occur in AD, including the accumulation of amyloid beta (Aβ), may serve as surrogate markers of brain Aβ levels. As Aβ has a wavelength-dependent effect on light scatter, we investigate the potential for in vivo retinal hyperspectral imaging to serve as a biomarker of brain Aβ. Significant differences in the retinal reflectance spectra are found between individuals with high Aβ burden on brain PET imaging and mild cognitive impairment (n = 15), and age-matched PET-negative controls (n = 20). Retinal imaging scores are correlated with brain Aβ loads. The findings are validated in an independent cohort, using a second hyperspectral camera. A similar spectral difference is found between control and 5xFAD transgenic mice that accumulate Aβ in the brain and retina. These findings indicate that retinal hyperspectral imaging may predict brain Aβ load.

    Original languageEnglish
    Article number4227
    Number of pages13
    JournalNature Communications
    Publication statusPublished - 17 Sep 2019

    Bibliographical note

    pen Access This article is licensed under a Creative Commons
    Attribution 4.0 International License, which permits use, sharing,
    adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder


    Dive into the research topics of 'Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer’s disease'. Together they form a unique fingerprint.

    Cite this