Non-steroidal anti-inflammatory drugs and atherothrombotic risk in older patients: where do we stand?

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    Abstract

    The evidence linking the use of non-steroidal anti-inflammatory drugs (NSAIDs) with increased atherothrombotic risk is controversial, particularly in older patients. This population is consistently underrepresented in epidemiological studies. Moreover, several confounding factors such as co-morbidities, polypharmacy, and institutionalisation might affect the interpretation of studies on the real association between NSAID use and cardiovascular risk. These issues are herewith discussed together with a proposed mechanism to explain the results of recent studies demonstrating a relatively low atherothrombotic risk associated with NSAIDs in older patients. Suggestions for future research directions are also provided.

    Original languageEnglish
    Article numberafq099
    Pages (from-to)530-533
    Number of pages4
    JournalAge and Ageing
    Volume39
    Issue number5
    DOIs
    Publication statusPublished - 27 Jul 2010

    Keywords

    • Ageing
    • Atherothrombotic risk
    • Cardiovascular system
    • Inflammation
    • Non-steroidal anti-inflammatory drugs

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