Farmaci antinfiammatori non steroidei e rischio di ictus nell'età avanzata: controversie e opportunità

Translated title of the contribution: Non-steroidal anti-inflammatory drugs and stroke risk in old age: Controversies and opportunities

    Research output: Contribution to journalReview article

    2 Citations (Scopus)

    Abstract

    Recent professional statements from established bodies, i.e. American Heart Association, European Medicines Agency, and Medicines and Healthcare products Regulatory Agency, have cautioned on the use of nonsteroidal anti-inflammatory drugs (NSAIDs) given the potential increase in atherothrombotic risk associated with their long-term use. However, pharmacoepidemiological studies on the association between NSAID use and the risk of stroke, one of the leading causes of death, disability, and institutionalisation in old age, have shown contrasting results. Notably, very few such studies have addressed the risk in the older population, in particular patients >75-80 years, perhaps the biggest consumer group of these drugs. This article reviews the current evidence on the association between NSAIDs and risk of stroke in the older population. It also discusses the potential clinical, demographic, and pathophysiological factors potentially accounting for the discrepancies in the results of the pharmacoepidemiological studies and provides suggestions for future research directions.

    Translated title of the contributionNon-steroidal anti-inflammatory drugs and stroke risk in old age: Controversies and opportunities
    Original languageItalian
    Pages (from-to)341-349
    Number of pages9
    JournalGiornale Italiano Di Cardiologia (Italian Journal of Cardiology)
    Volume12
    Issue number5
    DOIs
    Publication statusPublished - 1 May 2011

    Keywords

    • Ageing
    • Atherosclerosis
    • Non-steroidal anti-inflammatory drugs
    • Pharmacoepidemiology
    • Stroke
    • Thrombosis

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