Nonchemical elimination of inspiratory motor output via mechanical ventilation in sleep

Makato Satoh, Peter R. Eastwood, Curtis A. Smith, Jerome A. Dempsey

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

In six dogs studied in nonrapid eye movement (NREM) sleep, we found that the frequency, volume, and timing of application of mechanical ventilator breaths had marked and sustained inhibitory effects on diaphragm electromyogram (EMGdi). Single ventilator breaths of tidal volume (Vt) 75-200% of control caused apnea (up to three times eupneic expiratory time [Te]) when applied during the initial 25-65% of expiratory time. When continuous controlled mechanical ventilation (CMV) was applied with ventilator frequency increased as little as 1 cycle/min > eupnea and PaCO2 and Vt maintained at near eupneic control levels, EMGdi was silenced and triangularis sterni EMG (EMGts) became tonic within 2 to 5 ventilator cycles. On cessation of normocapnic CMV, apnea ensued with Te ranging from 1.2 to five times eupneic Te. The spontaneous Vt and EMGdi determined immediately after these prolonged apneas were also markedly reduced in amplitude. The larger the Vt applied during the isocapnic CMV (120-200% of eupnea) and the longer the duration of the CMV (3-90 s), the longer the duration of the postventilator apnea. Significant postventilator apneas and postapneic hypoventilation also occurred even when end-tidal CO2 pressure (PETCO2) was raised 3-5 mm Hg > eupnea (and 7-10 mm Hg > normal apneic threshold) throughout CMV trials at raised frequency and Vt. Our findings demonstrate that the increased frequency of CMV was critical to the elimination of inspiratory motor output and the onset of tonic expiratory muscle activity; furthermore, once EMGdi was silenced, the tidal volume and duration of the passive mechanical ventilation determined the magnitude of the short-term inhibition of inspiratory motor output after cessation of CMV.

Original languageEnglish
Pages (from-to)1356-1364
Number of pages9
JournalAmerican journal of respiratory and critical care medicine
Volume163
Issue number6
DOIs
Publication statusPublished - 1 May 2001
Externally publishedYes

Bibliographical note

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Copyright 2017 Elsevier B.V., All rights reserved.

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