Noninvasive Ventilation of Patients with Acute Respiratory Distress Syndrome: Insights from the LUNG SAFE Study

Giacomo Bellani, John G. Laffey, Tai Pham, Fabiana Madotto, Eddy Fan, Laurent Brochard, Andres Esteban, Luciano Gattinoni, Vesna Bumbasirevic, Lise Piquilloud, Frank Van Haren, Anders Larsson, Daniel F. McAuley, Philippe R. Bauer, Yaseen M. Arabi, Marco Ranieri, Massimo Antonelli, Gordon D. Rubenfeld, B. Taylor Thompson, Hermann WriggeArthur S. Slutsky, Antonio Pesenti, LUNG SAFE Investigators, ESICM Trials Group, F. Rios, T. Sottiaux, P. Depuydt, F. S. Lora, L. C. Azevedo, G. Bugedo, H. Qiu, M. Gonzalez, J. Silesky, V. Cerny, J. Nielsen, M. Jibaja, D. Matamis, J. L. Ranero, P. Amin, S. M. Hashemian, K. Clarkson, K. Kurahashi, A. Villagomez, A. A. Zeggwagh, L. M. Heunks, J. H. Laake, J. E. Palo, A. do Vale Fernandes, D. Sandesc, V. Bumbasierevic, N. Nin, J. A. Lorente, F. Abroug, L. McNamee, J. Hurtado, E. Bajwa, G. Démpaire, G. M. Francois, H. Sula, L. Nunci, A. Cani, A. Zazu, C. Dellera, C. S. Insaurralde, R. V. Alejandro, J. Daldin, M. Vinzio, R. O. Fernandez, L. P. Cardonnet, L. R. Bettini, M. C. Bisso, E. M. Osman, M. G. Setten, P. Lovazzano, J. Alvarez, V. Villar, N. C. Pozo, N. Grubissich, G. A. Plotnikow, D. N. Vasquez, S. Ilutovich, N. Tiribelli, A. Chena, C. A. Pellegrini, M. G. Saenz, E. Estenssoro, M. Brizuela, H. Gianinetto, P. E. Gomez, V. I. Cerrato, M. G. Bezzi, S. A. Borello, F. A. Loiacono, A. M. Fernandez, S. Knowles, C. Reynolds, D. M. Inskip, J. J. Miller, J. Kong, C. Whitehead, S. Bihari, A. Seven, A. Krstevski, H. J. Rodgers, R. T. Millar, T. E. Mckenna, I. M. Bailey, G. C. Hanlon, A. Aneman, J. M. Lynch, R. Azad, J. Neal, P. W. Woods, B. L. Roberts, M. R. Kol, H. S. Wong, K. C. Riss, T. Staudinger, X. Wittebole, C. Berghe, P. A. Bulpa, A. M. Dive, R. Verstraete, H. Lebbinck, P. Depuydt, J. Vermassen, P. Meersseman, H. Ceunen, J. I. Rosa, D. O. Beraldo, C. Piras, A. M. Rampinelli, A. P. Nassar, S. Mataloun, M. Moock, M. M. Thompson, C. H. Gonçalves, A. P. Antônio, A. Ascoli, R. S. Biondi, D. C. Fontenele, D. Nobrega, V. M. Sales, S. Shindhe, M. Aiman, John Laffey, F. Beloncle, K. G. Davies, R. Cirone, V. Manoharan, M. Ismail, E. C. Goligher, M. Jassal, E. Nishikawa, A. Javeed, G. Curley, N. Rittayamai, M. Parotto, N. D. Ferguson, S. Mehta, J. Knoll, A. Pronovost, S. Canestrini, A. R. Bruhn, P. H. Garcia, F. A. Aliaga, P. A. Farías, J. S. Yumha, C. A. Ortiz, J. E. Salas, A. A. Saez, L. D. Vega, E. F. Labarca, F. T. Martinez, N. G. Carreño, P. Lora, H. Liu, Haibo Qiu, L. Liu, R. Tang, X. Luo, Y. An, H. Zhao, Y. Gao, Z. Zhai, Z. L. Ye, W. Wang, W. Li, Q. Li, R. Zheng, W. Yu, J. Shen, X. Li, T. Yu, Y. Lu, Y. Q. Wu, X. B. Huang, Z. He, Yuanhua Lu, H. Han, F. Zhang, R. Sun, H. X. Wang, S. H. Qin, B. H. Zhu, J. Zhao, J. Liu, B. Li, J. L. Liu, F. C. Zhou, Q. J. Li, X. Y. Zhang, Z. Li-Xin, Q. Xin-Hua, L. Jiang, Y. N. Gao, X. Y. Zhao, Y. Li, X. L. Li, C. Wang, Q. Yao, R. Yu, K. Chen, H. Shao, B. Qin, Q. Q. Huang, W. H. Zhu, A. Y. Hang, M. X. Hua, Y. Li, Y. Xu, Y. D. Di, L. L. Ling, T. H. Qin, S. H. Wang, J. Qin, Y. Han, S. Zhou, M. P. Vargas, J. I. Silesky Jimenez, M. A. González Rojas, J. E. Solis-Quesada, C. M. Ramirez-Alfaro, J. Máca, P. Sklienka, J. Gjedsted, A. Christiansen, Jonas Nielsen, B. G. Villamagua, M. Llano, P. Burtin, G. Buzancais, P. Beuret, N. Pelletier, S. Mortaza, A. Mercat, J. Chelly

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    158 Citations (Scopus)

    Abstract

    Rationale: Noninvasive ventilation (NIV) is increasingly used in patients with acute respiratory distress syndrome (ARDS). The evidence supporting NIV use in patients with ARDS remains relatively sparse. Objectives: To determine whether, during NIV, the categorization of ARDS severity based on the PaO2/FIO2 Berlin criteria is useful. Methods: TheLUNGSAFE(Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure) study described the management of patients with ARDS. This substudy examines the current practice of NIV use in ARDS, the utility of the PaO2/FIO2 ratio in classifying patients receiving NIV, and the impact of NIV on outcome. MeasurementsandMain Results:Of2,813 patients with ARDS,436 (15.5%) were managed with NIV on Days 1 and 2 following fulfillment of diagnosticcriteria.Classification of ARDS severity based on PaO2/FIO2ratio was associated with an increase in intensity of ventilatory support, NIV failure, and intensive care unit (ICU) mortality. NIV failure occurred in 22.2% of mild, 42.3% of moderate, and 47.1% of patients with severe ARDS. Hospital mortality in patients with NIV success and failure was 16.1% and 45.4%, respectively. NIV use was independently associated with increased ICU (hazard ratio, 1.446 [95% confidence interval, 1.159-1.805]), but not hospital, mortality. In a propensity matched analysis, ICU mortality was higher in NIV than invasively ventilated patients with a PaO2/FIO2 lower than 150 mm Hg. Conclusions:NIV was used in 15% of patients with ARDS,irrespective of severity category. NIV seems to be associated with higher ICU mortality in patients with a PaO2/FIO2 lower than 150 mm Hg.

    Original languageEnglish
    Pages (from-to)67-77
    Number of pages11
    JournalAmerican journal of respiratory and critical care medicine
    Volume195
    Issue number1
    DOIs
    Publication statusPublished - 1 Jan 2017

    Keywords

    • Acute respiratory distress syndrome
    • Noninvasive ventilation
    • Observational studies

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