Nonvolumetric echocardiographic indices of right ventricular systolic function: validation with cardiovascular magnetic resonance and relationship with functional capacity

Darryl Leong, Suchi Grover, Payman Molaee, Adhiraj Chakrabarty, Mitra Shirazi, Yi Cheng, Amy Penhall, Rebecca Perry, Hugh Greville, Majo Joseph, Joseph Selvanayagam

    Research output: Contribution to journalArticlepeer-review

    40 Citations (Scopus)

    Abstract

    Purpose: Right ventricular (RV) systolic function as measured by right ventricular ejection fraction (RVEF) has long been recognized as an important predictor of outcome in heart failure patients. The echocardiographic measurement of RV volumes and RVEF is challenging, however, owing to the unique geometry of the right ventricle. Several nonvolumetric echocardiographic indices of RV function have demonstrated prognostic value in heart failure. Comparison studies of these techniques with each other using RVEF as a benchmark are limited, however. Furthermore, the contribution of these various elements of RV function to patient functional status is uncertain. We therefore aimed to: (1) Determine which nonvolumetric echocardiographic index correlates best with RVEF as determined by cardiac magnetic resonance (CMR) imaging (the accepted gold standard measure of RV systolic function) and (2) Ascertain which echocardiographic index best predicts functional capacity. Methods: Eighty-three subjects (66 with systolic heart failure and 17 healthy controls) underwent CMR, 2D echocardiography, and cardiopulmonary exercise testing for comparison of echocardiographic indices of RV function with CMR RVEF, 6-minute walk distance and VO 2 PEAK. Results: Speckle tracking strain RV strain exhibited the closest association with CMR RV ejection fraction. Indices of RV function demonstrated weak correlation with 6-minute walk distance, but basal RV strain rate by tissue velocity imaging had good correlation with VO 2 PEAK. Conclusion: Strain by speckle tracking echocardiography and strain rate by tissue velocity imaging may offer complementary information in the evaluation of RV contractility and its functional effects. (Echocardiography 2012;29:455-463)

    Original languageEnglish
    Pages (from-to)455-463
    Number of pages9
    JournalEchocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques
    Volume29
    Issue number4
    DOIs
    Publication statusPublished - Apr 2012

    Keywords

    • exercise tolerance
    • right ventricular
    • strain

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