Abstract
Norbornene derivatives were validated as probes for cysteine sulfenic acid on proteins and in live cells. Trapping sulfenic acids with norbornene probes is highly selective and revealed a different reactivity profile than the traditional dimedone reagent. The norbornene probe also revealed a superior chemoselectivity when compared to a commonly used dimedone probe. Together, these results advance the study of cysteine oxidation in biological systems.
Original language | English |
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Pages (from-to) | 594-598 |
Number of pages | 5 |
Journal | ACS Chemical Biology |
Volume | 14 |
Issue number | 4 |
Early online date | 2019 |
DOIs | |
Publication status | Published - 19 Apr 2019 |
Keywords
- Norbornene Probes
- Cysteine Sulfenic Acid
- proteins
- cells
- biological systems