Novel bacterial cellulose-poly (acrylic acid) hybrid hydrogels with controllable antimicrobial ability as dressings for chronic wounds

Clarence Chuah, Jing Wang, Javad Tavakoli, Youhong Tang

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)
36 Downloads (Pure)

Abstract

This investigation examines the combination of poly (acrylic acid) (PAA) and bacterial cellulose (BC) nanofibers to synthesize hydrogel hybrid composites used for wound dressing application. Amoxicillin (AM) was also grafted onto the composites for drug release. Fourier transform infrared analysis and scanning electron microscopy conducted revealed the structure and porosity of the composite being developed, as well as the successful fabrication of BC-PAA composites. The results of mechanical testing and hygroscopicity revealed that the composite shows higher stability than hydrogels which are currently used worldwide, albeit with a slight reduction in swelling capabilities. However, the composite was revealed to be responsive to a rise in pH values with an increase in composite swelling and drug release. These results together with their morphological characteristics suggest that BC-PAA hydrogel hybrid composite is a promising candidate for wound dressing application.

Original languageEnglish
Article number1323
Number of pages10
JournalPolymers
Volume10
Issue number12
Early online date29 Nov 2018
DOIs
Publication statusPublished - Dec 2018

Keywords

  • Antimicrobial
  • Hydrogel
  • Poly (acrylic acid), bacterial cellulose
  • Wound dressing

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