Novel Handheld Magnetometer Probe Based on Magnetic Tunnelling Junction Sensors for Intraoperative Sentinel Lymph Node Identification

A Cousins, G L Balalis, Sarah K Thompson, D Forero Morales, Aaron Mohtar, A B Wedding, Benjamin Thierry

    Research output: Contribution to journalArticlepeer-review

    12 Citations (Scopus)

    Abstract

    Using magnetic tunnelling junction sensors, a novel magnetometer probe for the identification of the sentinel lymph node using magnetic tracers was developed. Probe performance was characterised in vitro and validated in a preclinical swine model. Compared to conventional gamma probes, the magnetometer probe showed excellent spatial resolution of 4.0mm, and the potential to detect as few as 5μg of magnetic tracer. Due to the high sensitivity of the magnetometer, all first-tier nodes were identified in the preclinical experiments, and there were no instances of false positive or false negative detection. Furthermore, these preliminary data encourage the application of the magnetometer probe for use in more complex lymphatic environments, such as in gastrointestinal cancers, where the sentinel node is often in close proximity to other non-sentinel nodes, and high spatial resolution detection is required.

    Original languageEnglish
    Article number10842
    Number of pages10
    JournalScientific Reports
    Volume5
    Issue number10842
    DOIs
    Publication statusPublished - 2015

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