NRG1 gene in recurrent major depression: No association in a large-scale case - Control association study

Alexandra Schosser, Sarah Cohen-Woods, D. Gaysina, P. C. Chow, L. Martucci, Anne Farmer, A. Korszun, C. Gunasinghe, J Gray, N. Craddock, Michael Owen, Ian Craig, Peter McGuffin

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    Abstract

    The Neuregulin 1 (NRG1) gene was initially implicated in schizophrenia (SZ) and has recently been associated with bipolar disorder (BPD) in two studies. An association with major depressive disorder (MDD) has not yet been investigated but is warranted in view of the genetic overlap betweenMDDand BPD. We have performed a large-scale case-control study investigating the association between NRG1 polymorphisms and MDD, genotyping a selection of 14 single nucleotide polymorphisms (SNPs) spanning the NRG1 gene in a sample of 1,398 patients of White European ancestry with a diagnosis of MDD and 1,304 ethnically matched controls from three clinical sites in the UK. We found no single marker or haplotype associations that withstood correction for multiple testing. Our findings do not provide evidence thatNRG1 plays a role inMDDor that this gene explains part of the genetic overlap with BPD.

    Original languageEnglish
    Pages (from-to)141-147
    Number of pages7
    JournalAMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
    Volume153B
    Issue number1
    DOIs
    Publication statusPublished - Jan 2010

    Keywords

    • Affective disorders
    • Association
    • Depression
    • NRG1

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