NSAID-containing topical formulations that demonstrate chemopreventive activity

Allan Evans (Inventor), Ross McKinnon (Inventor)

Research output: Patent


Disclosed herein are chemopreventive methods and topical formulations for the prevention and treatment of ultraviolet light-induced skin cancers, pre-cancerous lesions, and hyperproliferative disorders in mammals, such as humans, utilizing doses of non-steroidal anti-inflammatory drugs. Low doses of non-steroidal anti-inflammatory drugs are present in the topical formulations and allow continued regular use over an extended period of time to prevent such disorders. In particular, the present invention is particularly suitable for non-melanoma skin cancers as these cancers tend to appear in areas of the skin that have had excess sun exposure (head, neck and arms) meaning that the chemopreventive agent would not need to be applied over the entire body of the typical patient. Moreover, it is possible to identify 'high-risk' individuals within the populations because people who report one episode of NMSC tend to have a high incidence of a subsequent episode.
Original languageEnglish
Patent numberWO2003061713A1
IPCA61K 007/40 ,007/48,031/192 ,A61P 17/16
Priority date6/12/02
Filing date24/01/03
Publication statusPublished - 19 Jun 2008

Bibliographical note

Australian Patent Office Application No. AU2003237034B2


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