Nudging towards COVID-19 and influenza vaccination uptake in medically at-risk children: EPIC study protocol of randomised controlled trials in Australian paediatric outpatient clinics

Bing Wang; Prabha Andraweera; Margaret Danchin; Christopher C. Blyth; Ivo Vlaev; Jason Ong; Jodie M. Dodd; Jennifer Couper; Thomas R. Sullivan; Jonathan Karnon; Nicola Spurrier; Michael Cusack; Dylan Mordaunt; Dimi Simatos; Gustaaf Dekker; Samantha Carlson; Jane Tuckerman; Nicholas Wood; Lisa J. Whop; Helen Marshall

doi:10.1136/bmjopen-2023-076194

Nudging towards COVID-19 and influenza vaccination uptake in medically at-risk children: EPIC study protocol of randomised controlled trials in Australian paediatric outpatient clinics

Bing Wang, Prabha Andraweera, Margaret Danchin, Christopher C. Blyth, Ivo Vlaev, Jason Ong, Jodie M. Dodd, Jennifer Couper, Thomas R. Sullivan, Jonathan Karnon, Nicola Spurrier, Michael Cusack, Dylan Mordaunt, Dimi Simatos, Gustaaf Dekker, Samantha Carlson, Jane Tuckerman, Nicholas Wood, Lisa J. Whop, Helen Marshall

College of Medicine and Public Health

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Abstract

Introduction

Children with chronic medical diseases are at an unacceptable risk of hospitalisation and death from influenza and SARS-CoV-2 infections. Over the past two decades, behavioural scientists have learnt how to design non-coercive € nudge' interventions to encourage positive health behaviours. Our study aims to evaluate the impact of multicomponent nudge interventions on the uptake of COVID-19 and influenza vaccines in medically at-risk children.

Methods and analyses

Two separate randomised controlled trials (RCTs), each with 1038 children, will enrol a total of approximately 2076 children with chronic medical conditions who are attending tertiary hospitals in South Australia, Western Australia and Victoria. Participants will be randomly assigned (1:1) to the standard care or intervention group. The nudge intervention in each RCT will consist of three text message reminders with four behavioural nudges including (1) social norm messages, (2) different messengers through links to short educational videos from a paediatrician, medically at-risk child and parent and nurse, (3) a pledge to have their child or themselves vaccinated and (4) information salience through links to the current guidelines and vaccine safety information. The primary outcome is the proportion of medically at-risk children who receive at least one dose of vaccine within 3 months of randomisation. Logistic regression analysis will be performed to determine the effect of the intervention on the probability of vaccination uptake.

Ethics and dissemination

The protocol and study documents have been reviewed and approved by the Women's and Children's Health Network Human Research Ethics Committee (HREC/22/WCHN/2022/00082). The results will be published via peer-reviewed journals and presented at scientific meetings and public forums.

Trial registration number NCT05613751.

Original language	English
Article number	e076194
Number of pages	9
Journal	BMJ Open
Volume	14
Issue number	2
DOIs	https://doi.org/10.1136/bmjopen-2023-076194
Publication status	Published - 17 Feb 2024

Keywords

COVID-19
Infectious diseases
Primary Prevention
Public health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1136/bmjopen-2023-076194Licence: CC BY

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Cite this

Wang, B., Andraweera, P., Danchin, M., Blyth, C. C., Vlaev, I., Ong, J., Dodd, J. M., Couper, J., Sullivan, T. R., Karnon, J., Spurrier, N., Cusack, M., Mordaunt, D., Simatos, D., Dekker, G., Carlson, S., Tuckerman, J., Wood, N., Whop, L. J., & Marshall, H. (2024). Nudging towards COVID-19 and influenza vaccination uptake in medically at-risk children: EPIC study protocol of randomised controlled trials in Australian paediatric outpatient clinics. BMJ Open, 14(2), Article e076194. https://doi.org/10.1136/bmjopen-2023-076194

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abstract = "Introduction Children with chronic medical diseases are at an unacceptable risk of hospitalisation and death from influenza and SARS-CoV-2 infections. Over the past two decades, behavioural scientists have learnt how to design non-coercive € nudge' interventions to encourage positive health behaviours. Our study aims to evaluate the impact of multicomponent nudge interventions on the uptake of COVID-19 and influenza vaccines in medically at-risk children. Methods and analyses Two separate randomised controlled trials (RCTs), each with 1038 children, will enrol a total of approximately 2076 children with chronic medical conditions who are attending tertiary hospitals in South Australia, Western Australia and Victoria. Participants will be randomly assigned (1:1) to the standard care or intervention group. The nudge intervention in each RCT will consist of three text message reminders with four behavioural nudges including (1) social norm messages, (2) different messengers through links to short educational videos from a paediatrician, medically at-risk child and parent and nurse, (3) a pledge to have their child or themselves vaccinated and (4) information salience through links to the current guidelines and vaccine safety information. The primary outcome is the proportion of medically at-risk children who receive at least one dose of vaccine within 3 months of randomisation. Logistic regression analysis will be performed to determine the effect of the intervention on the probability of vaccination uptake. Ethics and dissemination The protocol and study documents have been reviewed and approved by the Women's and Children's Health Network Human Research Ethics Committee (HREC/22/WCHN/2022/00082). The results will be published via peer-reviewed journals and presented at scientific meetings and public forums. Trial registration number NCT05613751.",

keywords = "COVID-19, Infectious diseases, Primary Prevention, Public health",

author = "Bing Wang and Prabha Andraweera and Margaret Danchin and Blyth, {Christopher C.} and Ivo Vlaev and Jason Ong and Dodd, {Jodie M.} and Jennifer Couper and Sullivan, {Thomas R.} and Jonathan Karnon and Nicola Spurrier and Michael Cusack and Dylan Mordaunt and Dimi Simatos and Gustaaf Dekker and Samantha Carlson and Jane Tuckerman and Nicholas Wood and Whop, {Lisa J.} and Helen Marshall",

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doi = "10.1136/bmjopen-2023-076194",

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Wang, B, Andraweera, P, Danchin, M, Blyth, CC, Vlaev, I, Ong, J, Dodd, JM, Couper, J, Sullivan, TR, Karnon, J , Spurrier, N, Cusack, M, Mordaunt, D, Simatos, D, Dekker, G, Carlson, S, Tuckerman, J, Wood, N, Whop, LJ & Marshall, H 2024, 'Nudging towards COVID-19 and influenza vaccination uptake in medically at-risk children: EPIC study protocol of randomised controlled trials in Australian paediatric outpatient clinics', BMJ Open, vol. 14, no. 2, e076194. https://doi.org/10.1136/bmjopen-2023-076194

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T1 - Nudging towards COVID-19 and influenza vaccination uptake in medically at-risk children

T2 - EPIC study protocol of randomised controlled trials in Australian paediatric outpatient clinics

AU - Wang, Bing

AU - Andraweera, Prabha

AU - Danchin, Margaret

AU - Blyth, Christopher C.

AU - Vlaev, Ivo

AU - Ong, Jason

AU - Dodd, Jodie M.

AU - Couper, Jennifer

AU - Sullivan, Thomas R.

AU - Karnon, Jonathan

AU - Spurrier, Nicola

AU - Cusack, Michael

AU - Mordaunt, Dylan

AU - Simatos, Dimi

AU - Dekker, Gustaaf

AU - Carlson, Samantha

AU - Tuckerman, Jane

AU - Wood, Nicholas

AU - Whop, Lisa J.

AU - Marshall, Helen

PY - 2024/2/17

Y1 - 2024/2/17

N2 - Introduction Children with chronic medical diseases are at an unacceptable risk of hospitalisation and death from influenza and SARS-CoV-2 infections. Over the past two decades, behavioural scientists have learnt how to design non-coercive € nudge' interventions to encourage positive health behaviours. Our study aims to evaluate the impact of multicomponent nudge interventions on the uptake of COVID-19 and influenza vaccines in medically at-risk children. Methods and analyses Two separate randomised controlled trials (RCTs), each with 1038 children, will enrol a total of approximately 2076 children with chronic medical conditions who are attending tertiary hospitals in South Australia, Western Australia and Victoria. Participants will be randomly assigned (1:1) to the standard care or intervention group. The nudge intervention in each RCT will consist of three text message reminders with four behavioural nudges including (1) social norm messages, (2) different messengers through links to short educational videos from a paediatrician, medically at-risk child and parent and nurse, (3) a pledge to have their child or themselves vaccinated and (4) information salience through links to the current guidelines and vaccine safety information. The primary outcome is the proportion of medically at-risk children who receive at least one dose of vaccine within 3 months of randomisation. Logistic regression analysis will be performed to determine the effect of the intervention on the probability of vaccination uptake. Ethics and dissemination The protocol and study documents have been reviewed and approved by the Women's and Children's Health Network Human Research Ethics Committee (HREC/22/WCHN/2022/00082). The results will be published via peer-reviewed journals and presented at scientific meetings and public forums. Trial registration number NCT05613751.

AB - Introduction Children with chronic medical diseases are at an unacceptable risk of hospitalisation and death from influenza and SARS-CoV-2 infections. Over the past two decades, behavioural scientists have learnt how to design non-coercive € nudge' interventions to encourage positive health behaviours. Our study aims to evaluate the impact of multicomponent nudge interventions on the uptake of COVID-19 and influenza vaccines in medically at-risk children. Methods and analyses Two separate randomised controlled trials (RCTs), each with 1038 children, will enrol a total of approximately 2076 children with chronic medical conditions who are attending tertiary hospitals in South Australia, Western Australia and Victoria. Participants will be randomly assigned (1:1) to the standard care or intervention group. The nudge intervention in each RCT will consist of three text message reminders with four behavioural nudges including (1) social norm messages, (2) different messengers through links to short educational videos from a paediatrician, medically at-risk child and parent and nurse, (3) a pledge to have their child or themselves vaccinated and (4) information salience through links to the current guidelines and vaccine safety information. The primary outcome is the proportion of medically at-risk children who receive at least one dose of vaccine within 3 months of randomisation. Logistic regression analysis will be performed to determine the effect of the intervention on the probability of vaccination uptake. Ethics and dissemination The protocol and study documents have been reviewed and approved by the Women's and Children's Health Network Human Research Ethics Committee (HREC/22/WCHN/2022/00082). The results will be published via peer-reviewed journals and presented at scientific meetings and public forums. Trial registration number NCT05613751.

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KW - Infectious diseases

KW - Primary Prevention

KW - Public health

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Nudging towards COVID-19 and influenza vaccination uptake in medically at-risk children: EPIC study protocol of randomised controlled trials in Australian paediatric outpatient clinics

Abstract

Keywords

UN SDGs

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