Rationale:longitudinal analyses we examined the hypotheses that EDS and previously diagnosed and undiagnosed OSA are associated withdepression prevalence and incidence in a population-based cohort of community dwelling Australian men. Depression was assessed using Beck’s Depression Inventory (BDI)/Centre for Epidemiological Studies Depression Scale (CES-D)Methods:in 1875 men aged 35-83 years at two time points approximately 5 years apart. A random sample of men without previously diagnosedOSA (n = 857) undertook at home polysomnography (PSG) and completed the Epworth Sleepiness Scale questionnaire. 1660 men withoutdepression at baseline were included in the longitudinal analysis of incident depression. Previously undiagnosed severe OSA (adjusted OR 1.9, 95% CI 1.07-3.70) was associated with depression prevalence in theResults:cross-sectional analyses even after adjustment for confounders and EDS. EDS (adjusted OR 2.4, 95% CI 1.40-3.95) was also associated withdepression. Men with previously undiagnosed OSA and EDS had 4.2 times greater odds of depression than subjects without OSA and EDSand 3.5 times greater odds of depression than individuals with either OSA or EDS alone. Both previously diagnosed OSA (OR 2.0, 95% CI1.15-3.45) and previously undiagnosed severe OSA (AHI ≥ 30) (OR 2.9, 95% CI 1.19-6.92)) at follow-up were significantly associated withdepression onset over a 5 year period. Other PSG parameters including O saturation, O desaturation and arousal index were not22associated with depression prevalence or incidence. Severe OSA and EDS are independently associated with depression prevalence and onset in men. Clinicians should recogniseConclusion:the risk of OSA in men recently diagnosed with depression, particularly if sleepiness is present.
|Number of pages||1|
|Journal||American Journal of Respiratory and Critical Care Medicine|
|Publication status||Published - May 2015|
|Event||American Thoracic Society 2015 International Conference - COLORADO CONVENTION CENTER, Denver, United States|
Duration: 15 May 2015 → 20 May 2015