Obstructive Sleep Apnoea: From pathogenesis to treatment: Current controversies and future directions

Peter Eastwood, A Malhotra, Lyle Palmer, E Kezirian, Richard Horner, Mary Ip, Robert Thurnheer, Nicholas Antic, D Hillman

    Research output: Contribution to journalReview articlepeer-review

    67 Citations (Scopus)

    Abstract

    Obstructive sleep apnoea (OSA) is a common disease, recognized as an independent risk factor for a range of clinical conditions, such as hypertension, stroke, depression and diabetes. Despite extensive research over the past two decades, the mechanistic links between OSA and other associated clinical conditions, including metabolic disorders and cardiovascular disease, remain unclear. Indeed, the pathogenesis of OSA itself remains incompletely understood. This review provides opinions from a number of leading experts on issues related to OSA and its pathogenesis, interaction with anaesthesia, metabolic consequences and comorbidities, cardiovascular disease, genetics, measurement and diagnosis, surgical treatment and pharmacotherapeutic targets.

    Original languageEnglish
    Pages (from-to)587-595
    Number of pages9
    JournalRespirology
    Volume15
    Issue number4
    DOIs
    Publication statusPublished - May 2010

    Keywords

    • Pathogenesis
    • Sleep apnoea syndrome
    • Treatment

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