Ocular disease in patients with ANCA-positive vasculitis

A Watkins, John Kempen, Dongseok Choi, Teresa Liesegang, Siddharth Pujari, Craig Newcomb, Robert Nussenblatt, J Rosenbaum, Jennifer Thorne, C. Foster, D Jabs, Grace Levy-Clarke, E Suhler, Justine Smith

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    36 Citations (Scopus)


    Anti-neutrophil cytoplasmic antibody (ANCA)-positive vasculitis-the term recently applied to Wegener's granulomatosis-is a rare multi-system inflammation characterized by necrotizing granulomas and vasculitis. We investigated the ocular manifestations of this disease in a group of patients drawn from five inflammatory eye disease clinics across the United States. Of 8,562 persons with ocular inflammation, 59 individuals were diagnosed with ANCA-positive vasculitis; 35 males and 21 females, aged 16 to 96 years, were included in this study. Ocular diagnoses were scleritis (75.0%), uveitis (17.9%), and other ocular inflammatory conditions (33.9%) including peripheral ulcer-ative keratitis and orbital pseudotumor. Mean duration of ocular disease was 4.6 years. Oral corticosteroids and other

    Original languageEnglish
    Pages (from-to)12-19
    Number of pages8
    JournalJournal of Ocular Biology, Diseases and Informatics
    Issue number1
    Publication statusPublished - Mar 2010


    • ANCA-positive vasculitis
    • Eye
    • Scleritis
    • Wegener's granulomatosis


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