Ocular disease in patients with ANCA-positive vasculitis

A Watkins; John Kempen; Dongseok Choi; Teresa Liesegang; Siddharth Pujari; Craig Newcomb; Robert Nussenblatt; J Rosenbaum; Jennifer Thorne; C. Foster; D Jabs; Grace Levy-Clarke; E Suhler; Justine Smith

doi:10.1007/s12177-009-9044-4

Ocular disease in patients with ANCA-positive vasculitis

A Watkins
, John Kempen
, Dongseok Choi
, Teresa Liesegang
, Siddharth Pujari
, Craig Newcomb
, Robert Nussenblatt
, J Rosenbaum
, Jennifer Thorne
, C. Foster
, D Jabs
, Grace Levy-Clarke
, E Suhler
, Justine Smith

Research output: Contribution to journal › Article › peer-review

66 Citations (Scopus)

Abstract

Anti-neutrophil cytoplasmic antibody (ANCA)-positive vasculitis-the term recently applied to Wegener's granulomatosis-is a rare multi-system inflammation characterized by necrotizing granulomas and vasculitis. We investigated the ocular manifestations of this disease in a group of patients drawn from five inflammatory eye disease clinics across the United States. Of 8,562 persons with ocular inflammation, 59 individuals were diagnosed with ANCA-positive vasculitis; 35 males and 21 females, aged 16 to 96 years, were included in this study. Ocular diagnoses were scleritis (75.0%), uveitis (17.9%), and other ocular inflammatory conditions (33.9%) including peripheral ulcer-ative keratitis and orbital pseudotumor. Mean duration of ocular disease was 4.6 years. Oral corticosteroids and other

Original language	English
Pages (from-to)	12-19
Number of pages	8
Journal	Journal of Ocular Biology, Diseases and Informatics
Volume	3
Issue number	1
DOIs	https://doi.org/10.1007/s12177-009-9044-4
Publication status	Published - Mar 2010

Keywords

ANCA-positive vasculitis
Eye
Scleritis
Wegener's granulomatosis

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10.1007/s12177-009-9044-4

Cite this

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title = "Ocular disease in patients with ANCA-positive vasculitis",

abstract = "Anti-neutrophil cytoplasmic antibody (ANCA)-positive vasculitis-the term recently applied to Wegener's granulomatosis-is a rare multi-system inflammation characterized by necrotizing granulomas and vasculitis. We investigated the ocular manifestations of this disease in a group of patients drawn from five inflammatory eye disease clinics across the United States. Of 8,562 persons with ocular inflammation, 59 individuals were diagnosed with ANCA-positive vasculitis; 35 males and 21 females, aged 16 to 96 years, were included in this study. Ocular diagnoses were scleritis (75.0\%), uveitis (17.9\%), and other ocular inflammatory conditions (33.9\%) including peripheral ulcer-ative keratitis and orbital pseudotumor. Mean duration of ocular disease was 4.6 years. Oral corticosteroids and other",

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AU - Watkins, A

AU - Kempen, John

AU - Choi, Dongseok

AU - Liesegang, Teresa

AU - Pujari, Siddharth

AU - Newcomb, Craig

AU - Nussenblatt, Robert

AU - Rosenbaum, J

AU - Thorne, Jennifer

AU - Foster, C.

AU - Jabs, D

AU - Levy-Clarke, Grace

AU - Suhler, E

AU - Smith, Justine

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Y1 - 2010/3

N2 - Anti-neutrophil cytoplasmic antibody (ANCA)-positive vasculitis-the term recently applied to Wegener's granulomatosis-is a rare multi-system inflammation characterized by necrotizing granulomas and vasculitis. We investigated the ocular manifestations of this disease in a group of patients drawn from five inflammatory eye disease clinics across the United States. Of 8,562 persons with ocular inflammation, 59 individuals were diagnosed with ANCA-positive vasculitis; 35 males and 21 females, aged 16 to 96 years, were included in this study. Ocular diagnoses were scleritis (75.0%), uveitis (17.9%), and other ocular inflammatory conditions (33.9%) including peripheral ulcer-ative keratitis and orbital pseudotumor. Mean duration of ocular disease was 4.6 years. Oral corticosteroids and other

AB - Anti-neutrophil cytoplasmic antibody (ANCA)-positive vasculitis-the term recently applied to Wegener's granulomatosis-is a rare multi-system inflammation characterized by necrotizing granulomas and vasculitis. We investigated the ocular manifestations of this disease in a group of patients drawn from five inflammatory eye disease clinics across the United States. Of 8,562 persons with ocular inflammation, 59 individuals were diagnosed with ANCA-positive vasculitis; 35 males and 21 females, aged 16 to 96 years, were included in this study. Ocular diagnoses were scleritis (75.0%), uveitis (17.9%), and other ocular inflammatory conditions (33.9%) including peripheral ulcer-ative keratitis and orbital pseudotumor. Mean duration of ocular disease was 4.6 years. Oral corticosteroids and other

KW - ANCA-positive vasculitis

KW - Eye

KW - Scleritis

KW - Wegener's granulomatosis

UR - https://www.scopus.com/pages/publications/78650195309

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DO - 10.1007/s12177-009-9044-4

M3 - Article

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JO - Journal of Ocular Biology, Diseases and Informatics

JF - Journal of Ocular Biology, Diseases and Informatics

IS - 1

ER -

Ocular disease in patients with ANCA-positive vasculitis

Abstract

Keywords

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