Ocular neovascularization following central retinal artery occlusion: prevalence and timing of onset

Adam Rudkin, Andrew Lee, Celia Chen

    Research output: Contribution to journalArticle

    25 Citations (Scopus)

    Abstract

    PURPOSE. Debate exists in the literature on the prevalence and etiology of neovascularization following central retinal artery occlusion (CRAO). The reported prevalence varies from 2.5% to 31.6%. We conducted a retrospective study to determine the prevalence of ocular neovascularization following acute CRAO in our institution. METHODS. A retrospective audit of consecutive patients with nonarteritic/thromboembolic CRAO presenting between 1997 and 2009 in a single tertiary teaching hospital. RESULTS. Thirty-three patients were identified as having nonarteritic CRAO, and of this cohort 6 patients (18.2%) developed ocular neovascularization. Neovascular glaucoma was present in 5 cases (15.2%); 2 of these presented through an emergency department with painful eyes, both at 16 weeks post CRAO. The other cases of neovascularization were detected on scheduled follow-ups. Mean time from retinal occlusive event to observed neovascularization was 8.5 weeks (range 2-16 weeks). One case of neovascularization was associated with hemodynamically significant ipsilateral carotid stenosis; no patient had proliferative diabetic retinopathy or other causes of neovascularization. CONCLUSIONS. The prevalence of neovascularization following acute CRAO in our population was 18.2% at an average of 8.5 weeks post CRAO. There was a temporal relationship between the 2 events and no other causes of neovascularization demonstrable in our cohort of patients. There is no consensus on the follow-up regimen post CRAO to detect ocular neovascularization complications. Our study suggests that neovascularization can occur early and regular follow-up especially in the first 4 months is important post CRAO.

    Original languageEnglish
    Pages (from-to)1042-1046
    Number of pages5
    JournalEuropean Journal of Ophthalmology
    Volume20
    Issue number6
    DOIs
    Publication statusPublished - 2010

    Keywords

    • Neovascular glaucoma
    • Neovascularization of the disc
    • Neovascularization of the iris
    • Retinal artery occlusion

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