Ocular parameters changes in the IRBP knockout mouse eye

Shanu Markand; Sara Wetzstein; Natecia Baskin; Ranjay Chakraborty; Priyanka Priyadarshani; Kevin Donaldson; Jeffrey Boatright; Machelle Pardue; John Nickerson

Ocular parameters changes in the IRBP knockout mouse eye

Shanu Markand, Sara Wetzstein, Natecia Baskin, Ranjay Chakraborty, Priyanka Priyadarshani, Kevin Donaldson, Jeffrey Boatright, Machelle Pardue, John Nickerson

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Abstract

Despite the high prevalence of myopia in the worldwide population, underlying mechanisms are unclear. Interphotoreceptor retinoid-binding protein (IRBP) is major protein of the subretinal space. It plays a crucial role in the visual cycle. Our laboratory previously reported eye size defects at postnatal day 8 (P8), profound myopia and retinal degeneration at P30 in the IRBP knockout (KO) mice, indicating a role for IRBP in eye development. The purpose of this study was to determine which ocular parameters affecting optical power are altered in IRBP KO mice.

Original language	English
Number of pages	2
Publication status	Published - Sept 2016
Externally published	Yes
Event	ARVO 2016 Annual Meeting - Seattle, United States Duration: 1 May 2016 → 5 May 2016

Conference

Conference	ARVO 2016 Annual Meeting
Abbreviated title	ARVO 2016
Country/Territory	United States
City	Seattle
Period	1/05/16 → 5/05/16

Bibliographical note

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. CC BY-NC-ND

Keywords

Interphotoreceptor retinoid-binding protein (IRBP)
myopia
mice

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Published versionFinal published version, 66.7 KBLicence: CC BY-NC-ND

https://iovs.arvojournals.org/article.aspx?articleid=2560318&resultClick=1Licence: CC BY-NC-ND

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title = "Ocular parameters changes in the IRBP knockout mouse eye",

abstract = "Despite the high prevalence of myopia in the worldwide population, underlying mechanisms are unclear. Interphotoreceptor retinoid-binding protein (IRBP) is major protein of the subretinal space. It plays a crucial role in the visual cycle. Our laboratory previously reported eye size defects at postnatal day 8 (P8), profound myopia and retinal degeneration at P30 in the IRBP knockout (KO) mice, indicating a role for IRBP in eye development. The purpose of this study was to determine which ocular parameters affecting optical power are altered in IRBP KO mice.",

keywords = "Interphotoreceptor retinoid-binding protein (IRBP), myopia, mice",

author = "Shanu Markand and Sara Wetzstein and Natecia Baskin and Ranjay Chakraborty and Priyanka Priyadarshani and Kevin Donaldson and Jeffrey Boatright and Machelle Pardue and John Nickerson",

note = "This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. CC BY-NC-ND; ARVO 2016 Annual Meeting, ARVO 2016 ; Conference date: 01-05-2016 Through 05-05-2016",

year = "2016",

month = sep,

language = "English",

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TY - CONF

T1 - Ocular parameters changes in the IRBP knockout mouse eye

AU - Markand, Shanu

AU - Wetzstein, Sara

AU - Baskin, Natecia

AU - Chakraborty, Ranjay

AU - Priyadarshani, Priyanka

AU - Donaldson, Kevin

AU - Boatright, Jeffrey

AU - Pardue, Machelle

AU - Nickerson, John

N1 - This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. CC BY-NC-ND

PY - 2016/9

Y1 - 2016/9

N2 - Despite the high prevalence of myopia in the worldwide population, underlying mechanisms are unclear. Interphotoreceptor retinoid-binding protein (IRBP) is major protein of the subretinal space. It plays a crucial role in the visual cycle. Our laboratory previously reported eye size defects at postnatal day 8 (P8), profound myopia and retinal degeneration at P30 in the IRBP knockout (KO) mice, indicating a role for IRBP in eye development. The purpose of this study was to determine which ocular parameters affecting optical power are altered in IRBP KO mice.

AB - Despite the high prevalence of myopia in the worldwide population, underlying mechanisms are unclear. Interphotoreceptor retinoid-binding protein (IRBP) is major protein of the subretinal space. It plays a crucial role in the visual cycle. Our laboratory previously reported eye size defects at postnatal day 8 (P8), profound myopia and retinal degeneration at P30 in the IRBP knockout (KO) mice, indicating a role for IRBP in eye development. The purpose of this study was to determine which ocular parameters affecting optical power are altered in IRBP KO mice.

KW - Interphotoreceptor retinoid-binding protein (IRBP)

KW - myopia

KW - mice

M3 - Abstract

T2 - ARVO 2016 Annual Meeting

Y2 - 1 May 2016 through 5 May 2016

ER -

Ocular parameters changes in the IRBP knockout mouse eye

Abstract

Conference

Bibliographical note

Keywords

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