Ocular parameters changes in the IRBP knockout mouse eye

Shanu Markand, Sara Wetzstein, Natecia Baskin, Ranjay Chakraborty, Priyanka Priyadarshani, Kevin Donaldson, Jeffrey Boatright, Machelle Pardue, John Nickerson

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Despite the high prevalence of myopia in the worldwide population, underlying mechanisms are unclear. Interphotoreceptor retinoid-binding protein (IRBP) is major protein of the subretinal space. It plays a crucial role in the visual cycle. Our laboratory previously reported eye size defects at postnatal day 8 (P8), profound myopia and retinal degeneration at P30 in the IRBP knockout (KO) mice, indicating a role for IRBP in eye development. The purpose of this study was to determine which ocular parameters affecting optical power are altered in IRBP KO mice.
Original languageEnglish
Number of pages2
Publication statusPublished - Sept 2016
Externally publishedYes
EventARVO 2016 Annual Meeting - Seattle, United States
Duration: 1 May 20165 May 2016


ConferenceARVO 2016 Annual Meeting
Abbreviated titleARVO 2016
Country/TerritoryUnited States

Bibliographical note

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. CC BY-NC-ND


  • Interphotoreceptor retinoid-binding protein (IRBP)
  • myopia
  • mice


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