Ocular syphilis

João M. Furtado, Milena Simões, Daniel Vasconcelos-Santos, Genevieve F. Oliver, Mudit Tyagi, Heloisa Nascimento, David L. Gordon, Justine R. Smith

Research output: Contribution to journalReview articlepeer-review

24 Citations (Scopus)


Multiple studies around the world suggest that syphilis is re-emerging. Ocular syphilis – with a wide range of presentations, most of which are subtypes of uveitis – has become an increasingly common cause of ocular inflammation over the past 20 years. Its rising incidence, diagnostic complexity, and manifestations that have only recently been characterized make ocular syphilis relevant from the public health, clinical, and scientific perspectives. We review the demographics, epidemiology, clinical features, ocular imaging findings, diagnosis, and medical management of this condition.

Original languageEnglish
Pages (from-to)440-462
Number of pages23
JournalSurvey of Ophthalmology
Issue number2
Early online date18 Jun 2021
Publication statusPublished - 1 Mar 2022


  • Ocular syphilis
  • Sexually transmitted infections
  • Syphilis
  • Syphilitic uveitis
  • Uveitis


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