Older Persons' and Their Caregivers' Perspectives and Experiences of Research Participation with Impaired Decision-Making Capacity: A Scoping Review

Annmarie Hosie, Slavica Kochovska, Nola Ries, Imelda Gilmore, Deborah Parker, Craig Sinclair, Caitlin Sheehan, Aileen Collier, Gideon A. Caplan, Mandy Visser, Xiaoyue Xu, Elizabeth Lobb, Linda Sheahan, Linda Brown, Wei Lee, Christine R. Sanderson, Ingrid Amgarth-Duff, Anna Green, Layla Edwards, Meera R. Agar

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

Background and Objectives: Human research ethics statements support the equitable inclusion of diverse groups. Yet older people are underrepresented in clinical research, especially those with impaired decision-making capacity. The aim of this study was to identify the perspectives and experiences of older persons and their caregivers of research participation with impaired decision-making capacity. 

Research Design and Methods: Scoping review of the literature and online sources in January-February 2019 (updated June 2020) according to Joanna Briggs Institute methodology and PRISMA Extension for Scoping Reviews. English-language peer-reviewed research articles and Australian online narratives were included. Data were tabulated and narratively synthesized. 

Results: From 4,171 database records and 93 online resources, 22 articles (2000-2019, 82% United States, 16 first authors) and one YouTube webinar (2018) were initially included; updated searches yielded an additional article (2020) and YouTube webinar (2020). Studies were heterogeneous in terminology, methods, and foci, with hypothetical scenarios, quantitative analyses, and examination of proxy consent predominating. Participants (N = 7,331) were older persons (71%), caregivers of older persons with dementia/cognitive impairment (23%), and older persons with dementia/cognitive impairment (6%). Synthesis identified 2 themes: willingness to participate and decision-making approaches. 

Discussion and Implications: Research participation by older persons with dementia may be optimized through reducing risks and burdens and increasing benefits for participants, greater consumer input into study development, and shared and supported decision-making. Older persons' and caregivers' perspectives and experiences of research participation with impaired decision-making capacity require investigation in a greater range of countries and conditions other than dementia, and dissemination through more varied media.

Original languageEnglish
Pages (from-to)E112-E122
Number of pages11
JournalGerontologist
Volume62
Issue number2
Early online date31 Aug 2020
DOIs
Publication statusPublished - Mar 2022
Externally publishedYes

Keywords

  • Analysis
  • Decision making
  • Dementia
  • Ethics (research, practice, policy, individual choices)

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