One-Carbon and Polyamine Metabolism as Cancer Therapy Targets

Anowarul Islam, Zeeshan Shaukat, Rashid Hussain, Stephen L. Gregory

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)
117 Downloads (Pure)


Cancer metabolic reprogramming is essential for maintaining cancer cell survival and rapid replication. A common target of this metabolic reprogramming is one-carbon metabolism which is notable for its function in DNA synthesis, protein and DNA methylation, and antioxidant production. Polyamines are a key output of one-carbon metabolism with widespread effects on gene expression and signaling. As a result of these functions, one-carbon and polyamine metabolism have recently drawn a lot of interest for their part in cancer malignancy. Therapeutic inhibitors that target one-carbon and polyamine metabolism have thus been trialed as anticancer medications. The significance and future possibilities of one-carbon and polyamine metabolism as a target in cancer therapy are discussed in this review.
Original languageEnglish
Article number1902
Number of pages24
Issue number12
Publication statusPublished - 19 Dec 2022


  • autophagy
  • cancer
  • metabolic therapy
  • methionine
  • one-carbon metabolism
  • polyamines
  • reactive oxygen species


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