TY - JOUR
T1 - Opioid PrEscRiptions and usage After Surgery (OPERAS)
T2 - protocol for a prospective multicentre observational cohort study of opioid use after surgery
AU - TASMAN Collaborative
AU - Pockney, Peter
AU - Basam, Aya
AU - Ferguson, Liam
AU - Gaborit, Lorane
AU - Goh, Sarah
AU - Hilder, Amie
AU - Jabur, Aiden
AU - Kalyanasundaram, Kaviya
AU - Ong, Chui Foong
AU - Park, Melissa
AU - Pathak, Upasana
AU - Raubenheimer, Kyle
AU - Siribaddana, Venesa
AU - Varghese, Chris
AU - Vu, Jennifer
AU - Wells, Cameron
AU - Xu, William
AU - Adeyeye, Ademola
AU - Alvarez-Lozada, Luis Adrian
AU - Vinod, Simran
AU - Buhavac, Milos
AU - Calini, Giacomo
AU - Daudu, Davina
AU - Atici, Semra Demirli
AU - Tepe, Mustafa Deniz
AU - Elhadi, Muhammed
AU - Ioannidis, Orestis
AU - Karthikeyan, Nandini
AU - Mansour, Laure Taher
AU - Nath, Upanmanyu
AU - Seow, Warren
AU - Singh, Surya
AU - Tasi, Zoya
AU - Uzair, Ahmad
AU - Yang, Wah
AU - Zaidi, Faseeh
AU - Atherton, Kristy
AU - Banerjee, Arnab
AU - Dawson, Amanda
AU - Dudi-Venkata, Nagendra
AU - Lightfoot, Nicholas
AU - Ludbrook, Isabella
AU - Martin, Jennifer
AU - Peters, Luke
AU - Richards, Toby
AU - Sara, Rachel
AU - Watson, David
AU - Wright, Deborah
N1 - Funding Information:
OPERAS has received funding from the Maurice and Phyllis Paykel Trust (Ref: 213122) and Surgical Research Funds, University of Newcastle.
Publisher Copyright:
© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2022/11
Y1 - 2022/11
N2 - Introduction Postoperative pain is common and frequently addressed through opioid analgesia. This practice must balance the benefits of achieving adequate pain relief against the harms of adverse effects such as opioid-induced ventilatory impairment and opioid use disorder. This student and trainee-led collaborative study aims to investigate and compare the prescription versus consumption of opioids at 7 days postdischarge after common surgical procedures and their impact on patient-reported outcomes regarding postoperative pain. Methods and analysis This is a prospective multicentre observational cohort study of surgical patients in Australia, Aotearoa New Zealand and select international sites, conducted by networks of students, trainees and consultants. Consecutive adult patients undergoing common elective and emergency general, orthopaedic, gynaecological and urological surgical procedures are eligible for inclusion, with follow-up 7 days after hospital discharge. The primary outcome will be the proportion of prescribed opioids consumed by patients at 7 days postdischarge. Secondary outcomes will include patient-reported quality of life and satisfaction scores, rate of non-opioid analgesic use, rate of continuing use of opioids at follow-up, rates of opioid prescription from other sources and hospital readmissions at 7 days postdischarge for opioid related side-effects or surgery-related pain. Descriptive and multivariate analyses will be conducted to investigate factors associated with opioid requirements and prescription-consumption discrepancies. Ethics and dissemination OPERAS has been approved in Australia by the Hunter New England Human Research Ethics Committee (Protocol 2021/ETH11508) and by the Southern Health and Disability Ethics Committee (2021 EXP 11199) in Aotearoa New Zealand. Results will be submitted for conference presentation and peer-reviewed publication. Centre-level data will be distributed to participating sites for internal audit.
AB - Introduction Postoperative pain is common and frequently addressed through opioid analgesia. This practice must balance the benefits of achieving adequate pain relief against the harms of adverse effects such as opioid-induced ventilatory impairment and opioid use disorder. This student and trainee-led collaborative study aims to investigate and compare the prescription versus consumption of opioids at 7 days postdischarge after common surgical procedures and their impact on patient-reported outcomes regarding postoperative pain. Methods and analysis This is a prospective multicentre observational cohort study of surgical patients in Australia, Aotearoa New Zealand and select international sites, conducted by networks of students, trainees and consultants. Consecutive adult patients undergoing common elective and emergency general, orthopaedic, gynaecological and urological surgical procedures are eligible for inclusion, with follow-up 7 days after hospital discharge. The primary outcome will be the proportion of prescribed opioids consumed by patients at 7 days postdischarge. Secondary outcomes will include patient-reported quality of life and satisfaction scores, rate of non-opioid analgesic use, rate of continuing use of opioids at follow-up, rates of opioid prescription from other sources and hospital readmissions at 7 days postdischarge for opioid related side-effects or surgery-related pain. Descriptive and multivariate analyses will be conducted to investigate factors associated with opioid requirements and prescription-consumption discrepancies. Ethics and dissemination OPERAS has been approved in Australia by the Hunter New England Human Research Ethics Committee (Protocol 2021/ETH11508) and by the Southern Health and Disability Ethics Committee (2021 EXP 11199) in Aotearoa New Zealand. Results will be submitted for conference presentation and peer-reviewed publication. Centre-level data will be distributed to participating sites for internal audit.
KW - clinical pharmacology
KW - pain management
KW - surgery
KW - opioid analgesics
KW - postoperative pain
UR - http://www.scopus.com/inward/record.url?scp=85142029144&partnerID=8YFLogxK
U2 - 10.1136/bmjopen-2022-063577
DO - 10.1136/bmjopen-2022-063577
M3 - Article
C2 - 36332960
AN - SCOPUS:85142029144
SN - 2044-6055
VL - 12
JO - BMJ Open
JF - BMJ Open
IS - 11
M1 - 063577
ER -