Optimising a vortex fluidic device for controlling chemical reactivity and selectivity

Lyzu Yasmin, Xianjue Chen, Keith Stubbs, Colin Raston

    Research output: Contribution to journalArticlepeer-review

    82 Citations (Scopus)


    A vortex fluidic device (VFD) involving a rapidly rotating tube open at one end forms dynamic thin films at high rotational speed for finite sub-millilitre volumes of liquid, with shear within the films depending on the speed and orientation of the tube. Continuous flow operation of the VFD where jet feeds of solutions are directed to the closed end of the tube provide additional tuneable shear from the viscous drag as the liquid whirls along the tube. The versatility of this simple, low cost microfluidic device, which can operate under confined mode or continuous flow is demonstrated in accelerating organic reactions, for model Diels-Alder dimerization of cyclopentadienes, and sequential aldol and Michael addition reactions, in accessing unusual 2,4,6-triarylpyridines. Residence times are controllable for continuous flow processing with the viscous drag dominating the shear for flow rates >0.1 mL/min in a 10 mm diameter tube rotating at >2000 rpm.

    Original languageEnglish
    Article number2282
    Pages (from-to)2282
    Number of pages6
    JournalScientific Reports
    Publication statusPublished - 25 Jul 2013


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