Oral disease in relation to future risk of dementia and cognitive decline: Prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial

George Batty; Qing Li; Rachel Huxley; Sophia Zoungas; Barbara Taylor; Bruce Neal; Bastiaan De Galan; Mark Woodward; Stephen Harrap; Stephen Colagiuri; Anushka Patel; John Chalmers

doi:10.1016/j.eurpsy.2011.07.005

Oral disease in relation to future risk of dementia and cognitive decline: Prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial

George Batty, Qing Li, Rachel Huxley, Sophia Zoungas, Barbara Taylor, Bruce Neal, Bastiaan De Galan, Mark Woodward, Stephen Harrap, Stephen Colagiuri, Anushka Patel, John Chalmers

Research output: Contribution to journal › Article › peer-review

88 Citations (Scopus)

Abstract

Objective: Examine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes. Methods: A total of 11,140 men and women aged 55-88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5-year follow-up. Results: Relative to the group with the greatest number of teeth (more than or equal to 22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95% confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes. Conclusions: Tooth loss was associated with an increased risk of both dementia and cognitive decline.

Original language	English
Pages (from-to)	49-52
Number of pages	4
Journal	EUROPEAN PSYCHIATRY
Volume	28
Issue number	1
DOIs	https://doi.org/10.1016/j.eurpsy.2011.07.005
Publication status	Published - 1 Jan 2013

Keywords

Cognitive decline
Cohort study
Dementia
Oral disease

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Batty, G., Li, Q., Huxley, R., Zoungas, S., Taylor, B., Neal, B., De Galan, B., Woodward, M., Harrap, S., Colagiuri, S., Patel, A., & Chalmers, J. (2013). Oral disease in relation to future risk of dementia and cognitive decline: Prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial. EUROPEAN PSYCHIATRY, 28(1), 49-52. https://doi.org/10.1016/j.eurpsy.2011.07.005

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title = "Oral disease in relation to future risk of dementia and cognitive decline: Prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial",

abstract = "Objective: Examine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes. Methods: A total of 11,140 men and women aged 55-88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5-year follow-up. Results: Relative to the group with the greatest number of teeth (more than or equal to 22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95% confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes. Conclusions: Tooth loss was associated with an increased risk of both dementia and cognitive decline.",

keywords = "Cognitive decline, Cohort study, Dementia, Oral disease",

author = "George Batty and Qing Li and Rachel Huxley and Sophia Zoungas and Barbara Taylor and Bruce Neal and {De Galan}, Bastiaan and Mark Woodward and Stephen Harrap and Stephen Colagiuri and Anushka Patel and John Chalmers",

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Batty, G, Li, Q, Huxley, R, Zoungas, S, Taylor, B, Neal, B, De Galan, B, Woodward, M, Harrap, S, Colagiuri, S, Patel, A & Chalmers, J 2013, 'Oral disease in relation to future risk of dementia and cognitive decline: Prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial', EUROPEAN PSYCHIATRY, vol. 28, no. 1, pp. 49-52. https://doi.org/10.1016/j.eurpsy.2011.07.005

Oral disease in relation to future risk of dementia and cognitive decline : Prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial. / Batty, George; Li, Qing; Huxley, Rachel et al.

In: EUROPEAN PSYCHIATRY, Vol. 28, No. 1, 01.01.2013, p. 49-52.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Oral disease in relation to future risk of dementia and cognitive decline

T2 - Prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial

AU - Batty, George

AU - Li, Qing

AU - Huxley, Rachel

AU - Zoungas, Sophia

AU - Taylor, Barbara

AU - Neal, Bruce

AU - De Galan, Bastiaan

AU - Woodward, Mark

AU - Harrap, Stephen

AU - Colagiuri, Stephen

AU - Patel, Anushka

AU - Chalmers, John

PY - 2013/1/1

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N2 - Objective: Examine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes. Methods: A total of 11,140 men and women aged 55-88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5-year follow-up. Results: Relative to the group with the greatest number of teeth (more than or equal to 22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95% confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes. Conclusions: Tooth loss was associated with an increased risk of both dementia and cognitive decline.

AB - Objective: Examine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes. Methods: A total of 11,140 men and women aged 55-88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5-year follow-up. Results: Relative to the group with the greatest number of teeth (more than or equal to 22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95% confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes. Conclusions: Tooth loss was associated with an increased risk of both dementia and cognitive decline.

KW - Cognitive decline

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Batty G, Li Q, Huxley R, Zoungas S, Taylor B, Neal B et al. Oral disease in relation to future risk of dementia and cognitive decline: Prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial. EUROPEAN PSYCHIATRY. 2013 Jan 1;28(1):49-52. https://doi.org/10.1016/j.eurpsy.2011.07.005

Oral disease in relation to future risk of dementia and cognitive decline: Prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial

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Keywords

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