Oral disease in relation to future risk of dementia and cognitive decline: Prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial

George Batty; Qing Li; Rachel Huxley; Sophia Zoungas; Barbara Taylor; Bruce Neal; Bastiaan De Galan; Mark Woodward; Stephen Harrap; Stephen Colagiuri; Anushka Patel; John Chalmers

doi:10.1016/j.eurpsy.2011.07.005

Oral disease in relation to future risk of dementia and cognitive decline: Prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial

George Batty
, Qing Li
, Rachel Huxley
, Sophia Zoungas
, Barbara Taylor
, Bruce Neal
, Bastiaan De Galan
, Mark Woodward
, Stephen Harrap
, Stephen Colagiuri
, Anushka Patel
, John Chalmers

Research output: Contribution to journal › Article › peer-review

110 Citations (Scopus)

Abstract

Objective: Examine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes. Methods: A total of 11,140 men and women aged 55-88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5-year follow-up. Results: Relative to the group with the greatest number of teeth (more than or equal to 22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95% confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes. Conclusions: Tooth loss was associated with an increased risk of both dementia and cognitive decline.

Original language	English
Pages (from-to)	49-52
Number of pages	4
Journal	EUROPEAN PSYCHIATRY
Volume	28
Issue number	1
DOIs	https://doi.org/10.1016/j.eurpsy.2011.07.005
Publication status	Published - 1 Jan 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cognitive decline
Cohort study
Dementia
Oral disease

Access to Document

10.1016/j.eurpsy.2011.07.005

Fingerprint

Dive into the research topics of 'Oral disease in relation to future risk of dementia and cognitive decline: Prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial'. Together they form a unique fingerprint.

Cite this

Batty, G., Li, Q., Huxley, R., Zoungas, S., Taylor, B., Neal, B., De Galan, B., Woodward, M., Harrap, S., Colagiuri, S., Patel, A., & Chalmers, J. (2013). Oral disease in relation to future risk of dementia and cognitive decline: Prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial. EUROPEAN PSYCHIATRY, 28(1), 49-52. https://doi.org/10.1016/j.eurpsy.2011.07.005

@article{4ae3eb13a4f34ea9a032ee53ef678e91,

title = "Oral disease in relation to future risk of dementia and cognitive decline: Prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial",

abstract = "Objective: Examine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes. Methods: A total of 11,140 men and women aged 55-88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5-year follow-up. Results: Relative to the group with the greatest number of teeth (more than or equal to 22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95\% confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes. Conclusions: Tooth loss was associated with an increased risk of both dementia and cognitive decline.",

keywords = "Cognitive decline, Cohort study, Dementia, Oral disease",

author = "George Batty and Qing Li and Rachel Huxley and Sophia Zoungas and Barbara Taylor and Bruce Neal and \{De Galan\}, Bastiaan and Mark Woodward and Stephen Harrap and Stephen Colagiuri and Anushka Patel and John Chalmers",

year = "2013",

month = jan,

day = "1",

doi = "10.1016/j.eurpsy.2011.07.005",

language = "English",

volume = "28",

pages = "49--52",

journal = "EUROPEAN PSYCHIATRY",

issn = "0924-9338",

publisher = "Cambridge University Press",

number = "1",

}

Batty, G, Li, Q, Huxley, R, Zoungas, S, Taylor, B, Neal, B, De Galan, B, Woodward, M, Harrap, S, Colagiuri, S, Patel, A & Chalmers, J 2013, 'Oral disease in relation to future risk of dementia and cognitive decline: Prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial', EUROPEAN PSYCHIATRY, vol. 28, no. 1, pp. 49-52. https://doi.org/10.1016/j.eurpsy.2011.07.005

Oral disease in relation to future risk of dementia and cognitive decline: Prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial. / Batty, George; Li, Qing; Huxley, Rachel et al.
In: EUROPEAN PSYCHIATRY, Vol. 28, No. 1, 01.01.2013, p. 49-52.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Oral disease in relation to future risk of dementia and cognitive decline

T2 - Prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial

AU - Batty, George

AU - Li, Qing

AU - Huxley, Rachel

AU - Zoungas, Sophia

AU - Taylor, Barbara

AU - Neal, Bruce

AU - De Galan, Bastiaan

AU - Woodward, Mark

AU - Harrap, Stephen

AU - Colagiuri, Stephen

AU - Patel, Anushka

AU - Chalmers, John

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Objective: Examine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes. Methods: A total of 11,140 men and women aged 55-88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5-year follow-up. Results: Relative to the group with the greatest number of teeth (more than or equal to 22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95% confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes. Conclusions: Tooth loss was associated with an increased risk of both dementia and cognitive decline.

AB - Objective: Examine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes. Methods: A total of 11,140 men and women aged 55-88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5-year follow-up. Results: Relative to the group with the greatest number of teeth (more than or equal to 22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95% confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes. Conclusions: Tooth loss was associated with an increased risk of both dementia and cognitive decline.

KW - Cognitive decline

KW - Cohort study

KW - Dementia

KW - Oral disease

UR - https://www.scopus.com/pages/publications/84872425950

U2 - 10.1016/j.eurpsy.2011.07.005

DO - 10.1016/j.eurpsy.2011.07.005

M3 - Article

SN - 0924-9338

VL - 28

SP - 49

EP - 52

JO - EUROPEAN PSYCHIATRY

JF - EUROPEAN PSYCHIATRY

IS - 1

ER -

Batty G, Li Q, Huxley R, Zoungas S, Taylor B, Neal B et al. Oral disease in relation to future risk of dementia and cognitive decline: Prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial. EUROPEAN PSYCHIATRY. 2013 Jan 1;28(1):49-52. doi: 10.1016/j.eurpsy.2011.07.005

Oral disease in relation to future risk of dementia and cognitive decline: Prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this