TY - JOUR
T1 - Organometallic palladium and platinum complexes with strongly donating alkyl coligands
T2 - synthesis, structures, chemical and cytotoxic properties
AU - Klein, Axel
AU - Lüning, Anna
AU - Ott, Ingo
AU - Hamel, Laura
AU - Neugebauer, Michael
AU - Butsch, Katharina
AU - Lingen, Verena
AU - Heinrich, Frank
AU - Elmas, Sait
PY - 2010/7/15
Y1 - 2010/7/15
N2 - The synthesis, spectroscopy, and structures of organometallic complexes [(COD)M(R)X] and [(COD)M(R)(R′)] (COD = 1,5-cyclooctadiene, M = Pd or Pt; R = methyl, neopentyl (2,2-dimethylpropyl), neosilyl (trimethylsilylmethyl), or benzyl; X = Cl, Br, or I; R′ = 2-phenyl-ethynyl, p-fluoro-2-phenyl- ethynyl, p-methyl-2-phenyl-ethynyl or p-nitro-2-phenyl-ethynyl) has been explored. Selected samples of organo-platinum complexes show strikingly high cytotoxicity when tested against HT-29 and MCF-7 tumour cells. Organo-palladium(II) and -platinum(II) complexes containing alkyl or alkynyl coligands and COD (1,5-cyclooctadiene) as chelating ligand were synthesised and thoroughly characterised by multinuclear NMR spectroscopy and XRD. Selected samples, namely the mixed alkyl alkynyl complexes, exhibit striking IC 50 values when tested against HT-29 and MCF-7 tumour cells.
AB - The synthesis, spectroscopy, and structures of organometallic complexes [(COD)M(R)X] and [(COD)M(R)(R′)] (COD = 1,5-cyclooctadiene, M = Pd or Pt; R = methyl, neopentyl (2,2-dimethylpropyl), neosilyl (trimethylsilylmethyl), or benzyl; X = Cl, Br, or I; R′ = 2-phenyl-ethynyl, p-fluoro-2-phenyl- ethynyl, p-methyl-2-phenyl-ethynyl or p-nitro-2-phenyl-ethynyl) has been explored. Selected samples of organo-platinum complexes show strikingly high cytotoxicity when tested against HT-29 and MCF-7 tumour cells. Organo-palladium(II) and -platinum(II) complexes containing alkyl or alkynyl coligands and COD (1,5-cyclooctadiene) as chelating ligand were synthesised and thoroughly characterised by multinuclear NMR spectroscopy and XRD. Selected samples, namely the mixed alkyl alkynyl complexes, exhibit striking IC 50 values when tested against HT-29 and MCF-7 tumour cells.
KW - organopalladium
KW - alkyl ligands
KW - transmetallation reactions
KW - cytotoxicity
KW - Alkyl ligands
KW - Alkynyl ligands
KW - Cytotoxicity
KW - Transmetallation reactions
KW - Organopalladium
KW - Organoplatinum
UR - http://www.scopus.com/inward/record.url?scp=77955418619&partnerID=8YFLogxK
U2 - 10.1016/j.jorganchem.2010.04.027
DO - 10.1016/j.jorganchem.2010.04.027
M3 - Article
VL - 695
SP - 1898
EP - 1905
JO - JOURNAL OF ORGANOMETALLIC CHEMISTRY
JF - JOURNAL OF ORGANOMETALLIC CHEMISTRY
SN - 0022-328X
IS - 15-16
ER -