Organoplatinum (II) and-palladium (II) complexes of nucleobases and their derivatives

Katharina Butsch, Sait Elmas, Nalinava Sen Gupta, Ronald Gust, Frank Heinrich, Axel Klein, Yvonne von Mering, Michael Neugebauer, Ingo Ott, Mathias Schäfer, Harald Scherer, Thilo Schurr

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

The [(COD)M(R)] 14 VE complex fragments (COD = 1,5-cyclooctadiene, R = methyl or neopentyl (2,2-dimethylpropyl), M = Pd or Pt) bind to the nucleobases cytosine (Cyt) or uracil (Ura), to the methylated nucleobase derivatives 1-methylcytosine (1MeCyt) or 1-methyluracil (1MeUra), and to the related ligand caffeine (Caf) (1,3,7-trimethylxanthine). From the potentially bridging cytosinate ligand a binuclear platinum complex [(COD)(Me)Pt(N3-cytosinate-N1)Pt(Me)(COD)]+ was obtained. The solubility of the corresponding complexes in organic solvents allowed their characterization by multiple (1H, 13C, and 195Pt) NMR spectroscopy and in some cases by crystal structure analysis. Relative ligand−metal bond strength were discussed in view of 1H−195Pt NMR coupling constants. Further focus lies on the observation of binding isomers, the formation of binuclear species, multiple substitution, and the observed differences between Pt and Pd derivatives. Cytotoxicity experiments on HT-29 colon carcinoma and MCF-7 breast cancer cell lines revealed promising activities for selected platinum COD complexes.
Original languageEnglish
Pages (from-to)3906-3915
Number of pages10
JournalOrganometallics
Volume28
Issue number13
DOIs
Publication statusPublished - 13 Jul 2009
Externally publishedYes

Fingerprint Dive into the research topics of 'Organoplatinum (II) and-palladium (II) complexes of nucleobases and their derivatives'. Together they form a unique fingerprint.

Cite this