Origin of serotonin innervation of the arcuate and ventromedial hypothalamic region

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    Combined fluorescence serotonin immunohistochemistry and retrograde transport labelling with Fast blue and Fluoro-gold were used to identify serotonin-immunoreactive neurons in the midbrain and pons which project to the region of the arcuate and ventromedial hypothalamic nuclei. Approximately 90% of doubly labelled neurons were located in the 3 major mesencephalic serotonin-containing cell groups: dorsal raphe (38%), median raphe (21%) and medial lemniscus group (29%). Within these groups, there were numerous non-retrogradely labelled serotonin-immunoreactive neurons as well as numerous non-serotonin-immunoreactive retrogradely labelled neurons. No doubly neurons were observed caudal to raphe pontis non-serotnin immunoreactive neurons were retrogradely labelled in the more caudal raphe nuclei.

    Original languageEnglish
    Pages (from-to)170-173
    Number of pages4
    JournalBrain Research
    Issue number1
    Publication statusPublished - 18 Aug 1987


    • Fast blue
    • Fluoro-gold
    • Immunohistochemistry
    • Medial basal hypothalamus
    • Midbrain
    • Pons
    • Serotonin


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